2014 Fiscal Year Final Research Report
Role of macrophages in the pathogenesis of HIV-1 infection
| Project/Area Number |
23300156
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | HIV / エイズ / マクロファージ / 多剤併用療法 / 半減期 / SHIV |
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| Outline of Final Research Achievements |
Macrophages have been known to be one of the major target cell types for HIV-1, the causative agent of AIDS. However, there are no available data concerning half-life of infected macrophages in infected individuals. Applying combined anti-retroviral regimen to SHIV-rhesus macaque model for AIDS, we revealed that there were at least three populations of infected macrophages with distinct half-lives and that the most durable population was consisted of M2 type macrophages. It is conceivable that specific intervention of these cells would contribute to the cure for the disease.
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| Free Research Field |
ウイルス学
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