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2013 Fiscal Year Final Research Report

Neural control and its impairment of flexible stability during human bipedal standing and walking

Research Project

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Project/Area Number 23300166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

NOMURA Taishin  大阪大学, 基礎工学研究科, 教授 (50283734)

Co-Investigator(Kenkyū-buntansha) SAKODA Saburo  国立病院機構刀根山病院, 院長 (00178625)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords立位姿勢 / 二足歩行 / 静止立位 / 運動制御 / 非線形力学系 / 間欠制御 / 安定性 / パーキンソン病
Research Abstract

We have proposed recently that human upright standing is stabilized in a flexible and robust manner by an intermittent control. In this study, we provided several evidences that support our hypothesis based on mathematical models of postural control and psychophysical experiments. We discussed possibility that a loss of intermittency in the neural control can be a cause of postural instability in patients with Parkinson's disease (PD). Moreover, we investigated a gait symptom called freezing of gait in PD patients, and suggested that a forceful but noisy neural control of interlimb coordination can be a main cause of the freezing of gait.

  • Research Products

    (26 results)

All 2014 2013 2012 2011

All Journal Article (11 results) Presentation (15 results)

  • [Journal Article] A theoretical study on a computational algorithm for human posture estimation based on motion capture of a small number of markers2014

    • Author(s)
      N Yoshikawa, Y Suzuki, K Kiyono, T Nomura
    • Journal Title

      Advanced Biomedical Engineering

      Volume: Vol.2 Pages: 107-116

  • [Journal Article] A new protocol for intermittent androgen suppression therapy of prostate cancer with unstable saddle-point dynamics2014

    • Author(s)
      Y Suzuki, D Sakai, T Nomura, Y Hirata, K Aihara
    • Journal Title

      Journal of Theoretical Biology

      Volume: 350 Pages: 1-16

  • [Journal Article] Noisy interlimb coordination can be a main cause of freezing of gait in patients with little to no parkinsonism2013

    • Author(s)
      T Tanahashi, T Yamamoto, T Endo, H Fujimura, M Yokoe, H Mochizuki, T Nomura, S Sakoda
    • Journal Title

      PLoS ONE

      Volume: Vol.8, No.12 Pages: e84423

  • [Journal Article] 人・社会のモデル化の最前線ヒトと人の数理モデルシミュレーション2013

    • Author(s)
      野村泰伸
    • Journal Title

      日本バーチャルリアリティ学会誌

      Volume: 18巻・3号 Pages: 160-163

  • [Journal Article] Nomura,Learning an Intermittent Control Strategy for Postural Balancing Using an EMG-Based Human-Computer Interface2013

    • Author(s)
      Y Asai, S Tateyama, T Nomura
    • Journal Title

      PLOS ONE

      Volume: Vol.8, No.5 Pages: e62956

  • [Journal Article] Modeling human postural sway using an intermittent control and hemodynamic perturbation2013

    • Author(s)
      T Nomura, S Oshikawa, Y Suzuki, K Kiyono, P Morasso
    • Journal Title

      Mathematical Biosciences

      Volume: Vol.245, No.1 Pages: 86-95

  • [Journal Article] Intermittent control with ankle, hip, and mixed strategies during quiet standing : A theoretical proposal based on a double inverted pendulum model2012

    • Author(s)
      Y Suzuki, T Nomura, M Casadio, P Morasso
    • Journal Title

      Journal of Theoretical Biology

      Volume: Vol.310 Pages: 55-79

  • [Journal Article] 4D human body posture estimation based on a motion capture system and a multi-rigid link model, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society2012

    • Author(s)
      N Yoshikawa, Y Suzuki, W Ozaki, T Yamamoto, T Nomura
    • Journal Title

      EMBS, art

      Volume: 6347079 Pages: 4847-4850

  • [Journal Article] Stability of double inverted pendulum model during human quiet stance with continuous delay feedback control , Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society2011

    • Author(s)
      Y Suzuki, T Nomura, P Morasso
    • Journal Title

      EMBS, art

      Volume: 6091747 Pages: 7450-7453

  • [Journal Article] A classification of postural sway patterns during upright stance in healthy adults and patients with Parkinson's disease2011

    • Author(s)
      T Yamamoto, Y Suzuki, K Nomura, T Nomura, T Tanahashi, K Fukada, T Endo, S Sakoda
    • Journal Title

      Journal of Advanced Computational Intelligence and Intelligent Informatics

      Volume: Vol.15, No.8 Pages: 997-1010

  • [Journal Article] ヒト静止立位姿勢の神経制御モデル2011

    • Author(s)
      野村泰伸
    • Journal Title

      日本神経回路学会誌

      Volume: Vol.18, No.2 Pages: 85-98

  • [Presentation] ヒト静止立位姿勢の神経制御に関する新しい仮説 : 姿勢ゆらぎ・多関節協調・姿勢障害の視点から2014

    • Author(s)
      野村泰伸
    • Organizer
      第12回姿勢と歩行研究会
    • Place of Presentation
      (pp.58-61)
    • Year and Date
      20140300
  • [Presentation] Bifurcation analysis of an intermittent control model during human quiet stance : A possible mechanism of postural sway2013

    • Author(s)
      T Nomura, Y Suzuki, T Yamamoto, K Kiyono, P Morasso
    • Organizer
      SIAM Conference on Applications of Dynamical Systems 2013
    • Place of Presentation
      (p.188)
    • Year and Date
      20130500
  • [Presentation] 生体システムにおける柔らかい制御-ホメオダイナミクスを考える,統計数理研究所共同研究リポート2013

    • Author(s)
      野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (vol.294, pp.77-93)
    • Year and Date
      20130300
  • [Presentation] パーキンソン病における固縮・振戦症状を再現する大脳基底核神経回路網モデルの構築,統計数理研究所共同研究リポート2013

    • Author(s)
      尺田博之, 野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (Vol.294, pp.54-63)
    • Year and Date
      20130300
  • [Presentation] 間欠的制御によるヒト静止立位二重振子モデルの安定化,統計数理研究所共同研究リポート2013

    • Author(s)
      鈴木康之, Pietro Morasso, 野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (Vol.294, pp.1-15)
    • Year and Date
      20130300
  • [Presentation] 柔軟かつ安定なヒト立位姿勢の神経制御とその崩壊メカニズム2012

    • Author(s)
      野村泰伸
    • Organizer
      第47回京都駅前セミナー
    • Year and Date
      20121100
  • [Presentation] Stability examination of biped model by Floquet theory,Proceedings of the 27th Symposium on Biological and Physiological Engineering BPES20122012

    • Author(s)
      Chunjiang Fu, Y Suzuki, K Kiyono, T Nomura
    • Organizer
      第27回生体・生理工学シンポジウム論文集
    • Year and Date
      20120900
  • [Presentation] 呼吸・心循環系動態とヒト静止立位姿勢動揺の関係2012

    • Author(s)
      押川翔太, 鈴木康之, 清野健, 野村泰伸
    • Organizer
      生体医工学シンポジウム2012 JBMES2012
    • Year and Date
      20120900
  • [Presentation] Intermittent Control and Homoclinic Cycle as Underlying Mechanisms of Stochastic Postural Sway with Long-Term Correlation during Human Quiet Standing2012

    • Author(s)
      T Nomura, T Yamamoto, Y Suzuki
    • Organizer
      BIOCOMP2012 Mathematical Modeling and Computational Topics in Biosciences
    • Place of Presentation
      (p.134)
    • Year and Date
      20120600
  • [Presentation] 健常者およびパーキンソン病患者の重心動揺のパターン分類に対する統計的検証2012

    • Author(s)
      山本智久, Smith C.E., 鈴木康之, 棚橋貴夫, 遠藤卓行, 佐古田三郎, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Year and Date
      20120500
  • [Presentation] モーションキャプチャによる次元姿勢推定に体表面上のマーカ変位が及ぼす影響2012

    • Author(s)
      吉川直也, 鈴木康之, 尾崎航, 山本智久, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Year and Date
      20120500
  • [Presentation] ヒト静止立位の倒立二重振子間欠制御モデル2012

    • Author(s)
      鈴木康之, Pietro Morasso, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Year and Date
      20120500
  • [Presentation] ヒト静止立位時の微弱皮膚感覚刺激が重心動揺に与える影響2011

    • Author(s)
      吉田信久, 鈴木康之, 野村泰伸
    • Organizer
      生体医工学シンポジウム2011
    • Year and Date
      20110900
  • [Presentation] Slow Fluctuations with long-term correlations in postural sway during human quiet standing2011

    • Author(s)
      T Nomura
    • Organizer
      第26回生体・生理工学シンポジウム論文集, BPES2011
    • Place of Presentation
      (pp.552-553)
    • Year and Date
      20110900
  • [Presentation] Dynamics of neuronal network models with a large number of ion-channel-based interneuron models for motor pattern generation2011

    • Author(s)
      K Okawa, T Nomura
    • Organizer
      第26回生体・生理工学シンポジウム論文集, BPES2011
    • Place of Presentation
      (pp.297-298)
    • Year and Date
      20110900

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Published: 2015-06-25  

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