2013 Fiscal Year Final Research Report
Comprehensive Analysis of Structure and Contractile Performance of Myocardium during Development
| Project/Area Number |
23300172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kazufumi 岡山大学, 岡山大学病院, 准教授 (10335630)
KATAOKA Noriyuki 川崎医療福祉大学, 医療技術学部, 教授 (20250681)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 心筋線維 / 心臓 / 発達 / X線回折 |
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| Research Abstract |
Isolated adult cardiomyocytes show rod shape with clear transverse striation pattern. However, isolated neonatal rat cardiomyocytes or induced cardiomyocytes of embryonic stem cells show star shape without clear transverse striation pattern. To analyze the development of structure of myofilament of cardiomyocytes, we performed x-ray diffraction analysis using Spring-8. We found that myofilament of neonatal rat heart had poor aligned myofilament lattice. the averaged inter filament lattice spacing was not so different during development over two weeks, deviation of interfilament lattice spacing was quite large at birth and decreased with development. We also considered how the poorly developed myofilament creates enough pressure to perfuse whole body. According to Laplace's law, small ventriclele requires small tension to create the enough pressure. Then, the well aligned myofilament can provide enough pressure even in the well developed ventricle.
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Research Products
(9 results)
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[Journal Article] Increased passive stiffness of cardiomyocytes in the transverse direction and residual actin and myosin cross-bridge formation in hypertrophied rat hearts induced by chronic β-adrenergic stimulation2013
Author(s)
Sumita Yoshikawa W, Nakamura K, Miura D, Shimizu J, Hashimoto K, Kataoka N, Toyota H, Okuyama H, Miyoshi T, Morita H, Fukushima Kusano K, Matsuo T, Takaki M, Kajiya F, Yagi N, Ohe T, Ito H
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Journal Title
Circ J
Volume: 77(3)
Pages: 741-8
Peer Reviewed
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