• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Comprehensive Analysis of Structure and Contractile Performance of Myocardium during Development

Research Project

  • PDF
Project/Area Number 23300172
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHiroshima International University

Principal Investigator

SHIMIZU Juichiro  広島国際大学, 保健医療学部, 教授 (80294403)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kazufumi  岡山大学, 岡山大学病院, 准教授 (10335630)
KATAOKA Noriyuki  川崎医療福祉大学, 医療技術学部, 教授 (20250681)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords心筋線維 / 心臓 / 発達 / X線回折
Research Abstract

Isolated adult cardiomyocytes show rod shape with clear transverse striation pattern. However, isolated neonatal rat cardiomyocytes or induced cardiomyocytes of embryonic stem cells show star shape without clear transverse striation pattern. To analyze the development of structure of myofilament of cardiomyocytes, we performed x-ray diffraction analysis using Spring-8. We found that myofilament of neonatal rat heart had poor aligned myofilament lattice. the averaged inter filament lattice spacing was not so different during development over two weeks, deviation of interfilament lattice spacing was quite large at birth and decreased with development. We also considered how the poorly developed myofilament creates enough pressure to perfuse whole body. According to Laplace's law, small ventriclele requires small tension to create the enough pressure. Then, the well aligned myofilament can provide enough pressure even in the well developed ventricle.

  • Research Products

    (9 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Energy for myocardial Ca^<2+> handling per beat increases with heart rate in excised cross-circulated canine heart2014

    • Author(s)
      Kiyooka T, Oshima Y, Fujinaka W, Iribe G, Mohri S, Shimizu J
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 39(1) Pages: 51-8

    • Peer Reviewed
  • [Journal Article] Increased passive stiffness of cardiomyocytes in the transverse direction and residual actin and myosin cross-bridge formation in hypertrophied rat hearts induced by chronic β-adrenergic stimulation2013

    • Author(s)
      Sumita Yoshikawa W, Nakamura K, Miura D, Shimizu J, Hashimoto K, Kataoka N, Toyota H, Okuyama H, Miyoshi T, Morita H, Fukushima Kusano K, Matsuo T, Takaki M, Kajiya F, Yagi N, Ohe T, Ito H
    • Journal Title

      Circ J

      Volume: 77(3) Pages: 741-8

    • Peer Reviewed
  • [Journal Article] Effects of propofol on left ventricular mechanoenergetics in the excised cross-circulated canine heart2012

    • Author(s)
      Fujinaka W, Shimizu J, Iribe G, Imaoka T, Oshima Y, Kiyooka T, Morita K, Mohri S
    • Journal Title

      Acta Med Okayama

      Volume: 66(6) Pages: 435-42

    • Peer Reviewed
  • [Journal Article] Cardiac dysfunction and prolonged hemodynamic deterioration after implantable cardioverter-defibrillator shock in patients with systolic heart failure2012

    • Author(s)
      Toh N, Nishii N, Nakamura K, Tada T, Oe H, Nagase S, Kohno K, Morita H, Kusano KF, Ito H
    • Journal Title

      Circ Arrhythm Electrophysiol. 2012 Oct

      Volume: 5(5) Pages: 898-905

    • DOI

      10.1161/CIRCEP.111.970285

    • Peer Reviewed
  • [Presentation] Cellular basis analyses of afterload dependent increasing in crossbridge formation in ejecting rat heart2013

    • Author(s)
      Yamato Tamura, Kengo Horiuchi, Takehiro Miyasaka, Juichiro Shimizu
    • Organizer
      International Union of Physiological Science 2013
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      20130721-26
  • [Presentation] Afterload dependent increasing in crossbridge formation in ejecting rat2013

    • Author(s)
      Yamato Tamura, Kengo Horiuchi, Takehiro Miyasaka, Juichiro Shimizu
    • Organizer
      International Society for Heart Research
    • Place of Presentation
      Sandiego, USA
    • Year and Date
      20130630-0704
  • [Presentation] Cellular basis analyses of afterload dependent increasing in crossbridge formation in ejecting rat2012

    • Author(s)
      Yamato Tamura, Takehiro Miyasaka, Juichiro Shimizu
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20121026-27
  • [Presentation] Increased Heart Rate Reduced Crossbridge Formation in Beating Rat Whole Heart2012

    • Author(s)
      Yamato Tamura, Takehiro Miyasaka, Juichiro Shimizu
    • Organizer
      IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI2012)
    • Place of Presentation
      Shenzhen, China
    • Year and Date
      20120105-07
  • [Presentation] ラット新生児の心筋六角格子発達過程についての基礎解析2011

    • Author(s)
      竹内祐貴, 中村一文, 三浦大志, 清水壽一郎
    • Organizer
      第34回日本生体医工学会中国四国支部大会
    • Place of Presentation
      徳島, 日本
    • Year and Date
      2011-10-22

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi