2013 Fiscal Year Final Research Report
Effective Production of Disease-Related Oligosaccharides and Preparation of Medical Devices
| Project/Area Number |
23300176
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Kyosuke 筑波大学, 学長 (40180492)
SUZUKI Tetsuro 浜松医科大学, 医学部, 教授 (00250184)
KASUYA Maria Carmelita 東京大学, 生産技術研究所, 助教 (30334361)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | オリゴ糖 / インフルエンザウイルス / シアリルラクトース / 細胞培養 / ガングリオシド / テトラフェニルエチレン / 診断分子 / クリック反応 |
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| Research Abstract |
A method to produce oligosaccharides, which interact with viruses or pathogenic proteins, by using cellular enzymes and donor substrate was established. The obtained oligosaccharides were used for the trial manufacture of the medical devices. Two kinds of molecules, which can detect human and avian influenza viruses, respectively, were developed by binding the oligosaccharides to the tetraphenylethylene which gives the fluorescence in high concentration. In addition, using the cytology molecules which could monitor intracellular oligosaccharide synthesis, searching the drug which could control oligosaccharide synthesis was attempted.
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Research Products
(23 results)
