2013 Fiscal Year Final Research Report
Creation of intelligent nanocarrier by effector-function elaboration to polymer materials
| Project/Area Number |
23300179
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
HARADA Atsushi 大阪府立大学, 工学(系)研究科(研究院), 准教授 (50302774)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 遺伝子治療 / ナノキャリア / 多分岐ポリエチレングリコール / ポリ-L-リシン / ナノファイバーポリプレックス |
|---|
| Research Abstract |
The functional elaborations including stability in serum medium, cellular uptake, cellular distribution and transcription / translation process are important in the development of the gene vector. Many studies have been performed for these subjects, but there are only a few reports on the promotion of efficiency of a transcription process yet. In this study, we developed the polymeric materials that could exhibit effective a transcription / the translation efficiency and also clarify the mechanism for these materials. Furthermore, we achieved the effective gene expression through the combination of the developed polymeric materials with cationic lipids.
|
