2013 Fiscal Year Final Research Report
Protein and stem cell-delivery systems using nanoparticles of narural polymer composites
| Project/Area Number |
23300181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Defense Medical College |
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Principal Investigator |
ISHIHARA Masayuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 教授 (10508500)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Miya 防衛医科大学校, 医学教育部医学科専門課程, 教授 (30505342)
MAEHARA Masaaki 防衛医科大学校, 医学教育部医学科専門課程, 教授 (70124956)
KIYOSAWA Tomoharu 防衛医科大学校, 病院, 准教授 (90221217)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生体材料 / 生物・生体工学 / ナノ材料 / 移植・再生医療 / 再生医学 |
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| Research Abstract |
Fragmin/protamine micro/nanoparticles (F/P M/NPs) were evaluated as a carrier for growth factors such as FGF and HGF and PRP (platelet-rich plasma) derived functional proteins. In addition, F/P M/NPs in combination with adipose-derived stromal cells (ASCs), are a new convenient cell carrier and may be a promising novel therapy for inducing vascularization and healing healing-impaired wounds in ischemic disease by transplantation of the ASCs/F/P M/NPs s-aggregates. Thus, LMW-H/P MPs are an excellent carrier for GFs and various cells such as ASCs. Clinical research was performed using autologous PRP/F/P M/NPs. Hair growth and thickening following the administration was observed in all patients compared with the control and its efficiency and safety were demonstrated.
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[Journal Article] Effective wound healing in streptozotocin-induced diabetic rats by adipose-derived stromal cell-transplantation in plasma-gel containing fragmin/protamine microparticles2014
Author(s)
Sumi Y, Ishihara M, Kishimoto S, Takikawa M, Hattori H, Takikawa M, Doumoto T, Azuma R, Nakamura S, Fujita M, Kiyosawa T
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Journal Title
Annals of Plastic Surgery
Volume: 72
Pages: 113-120
DOI
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[Journal Article] Selective Expansion of CD34+ Cells from Mouse Bone Marrow Cultured on LH/P MP-Coated Plates with Adequate Cytokines2011
Author(s)
Kishimoto S, Ishihara M, Kanatani Y, Nambu M, Takikawa M, Sumi Y, Nakamura S, Mori Y, Hattori H, Tanaka Y, Sato T
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Journal Title
J. Tissue Engineer
Volume: 30
Pages: 1-8
DOI
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[Journal Article] Stimilation of vascularization and granulation tisuue formation by growth factors in human platelet-rich plasma (PRP) containing fragmin/protamine micro particles (F/P MPs)2011
Author(s)
Takikawa M, Nakamura S-I, Nakamura S, Nambu M, Ishihara M, Murakami K, Kishimoto S, Sasaki K, Yanagishita S, Azuma R, Yamamoto N, Kiyosawa T
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Journal Title
J. Biomed. Mater. Res(B)
Volume: 97B (2)
Pages: 373-380
DOI
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