2013 Fiscal Year Final Research Report
A new therapeutic strategy against chronic heart failure: chronic vagal nerve stimulation
| Project/Area Number |
23300191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kochi University |
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Principal Investigator |
SATO Takayuki 高知大学, 教育研究部医療学系, 教授 (90205930)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Fumiyasu 高知大学, 教育研究部医療学系, 講師 (10243841)
KAKINUMA Yoshihiko 高知大学, 教育研究部医療学系, 准教授 (40233944)
ARIKAWA Mikihiko 高知大学, 教育研究部医療学系, 助教 (20432817)
NOGUCHI Tatuya 高知大学, 教育研究部医療学系, 助教 (50566495)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 臓器保存・治療システム / 循環器・高血圧 / ﾄﾗﾝｽﾚｰｼｮﾅﾙﾘｻｰﾁ / 神経ｲﾝﾀｰﾌｪｰｽ |
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| Research Abstract |
There is always a need for better intervention or drugs to reduce a high mortality rate and to improve a quality of life in patients with chronic heart failure (CHF). A line of clinical evidence indicates that prevention of mechanical, electrical, and metabolic remodeling is essential for improvement of the prognosis. In the present study, we developed an implantable device for chronic vagal nerve stimulation (VNS) and investigated the effects of VNS on mechanical, electrical, and metabolic remodeling in CHF rats after large myocardial infarction. The VNS therapy improved end-systolic elastance of the left ventricle and prevented ventricular dilatation, preserved electrical stability of the heart through upregulation of gap junction proteins, and enhanced glucose uptake by cardiomyocytes and intracellular ATP reserve. These results suggest that the chronic VNS therapy is useful for the treatment of CHF.
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