A multi-modal rehabilitation approach that used cartilage stem cell as a subject

2013 Fiscal Year Final Research Report

• Project/Area Number: 23300199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: AOYAMA Tomoki 京都大学, 医学(系)研究科(研究院), 准教授 (90378886)
• Co-Investigator(Kenkyū-buntansha): 高桑 徹也 京都大学, 教授 (40244933) ; 黒木 裕士 京都大学, 教授 (20170110) ; 三浦 美樹子 島根大学, 助教 (40447925)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: リハビリテーション / マルチモダル / 軟骨幹細胞 / 生体内シグナル

Research Abstract

In the field of rehabilitation, the analysis was carried out mainly for an individual and the group. It was hard to build the evidence not to adjust to statistics technique, and the compatibility with other domains was poor.
This study aimed for establishment of new multidisciplinary rehabilitation, clarifying the existence of the cartilage stem cell and receptor signalling, when performing excercise. This approach may produce the new aspect of rehabilitation targeting the individual, organ, cell, and molecules.

Research Products

• [Journal Article] Optimum temperature for extracellular matrix production by articular chondrocytes (2014)
  • Author(s): Ito A, Aoyama T, Iijima H, Nagai M, Yamaguchi S, Tajino J, Zhang X, Akiyama H, Kuroki H
  • Journal Title: Int J Hyperthermia Volume: 30(2) Pages: 96-101
• [Journal Article] Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load (2014)
  • Author(s): Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, Yamaguchi S, Akiyama H, Kuroki H
  • Journal Title: BMC Musculoskelet Disord Volume: 15(1) Pages: 101
• [Journal Article] The layered structure of the articular surface (2013)
  • Author(s): Fujioka R, Aoyama T, Takakuwa T
  • Journal Title: Osteoarthritis Cartilage Volume: 21(8) Pages: 1092-8
• [Journal Article] Effects of exercise level on biomarkers in a rat knee model of osteoarthritis (2013)
  • Author(s): Yamaguchi S, Aoyama T, Ito A, Nagai M, Iijima H, Zhang X, Tajino J, Kuroki H
  • Journal Title: J Orthop Res Volume: 31(7) Pages: 1026-31
• [Journal Article] Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix metalloproteinase-13 induced by interleukin-1β in chondrocytes in an intensity-dependent manner (2012)
  • Author(s): Ito A, Aoyama T, Yamaguchi S, Zhang X, Akiyama H, Kuroki H
  • Journal Title: Ultrasound Med Biol Volume: 38(10) Pages: 1726-33
• [Journal Article] Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability (2011)
  • Author(s): Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J
  • Journal Title: Arthritis Res Ther Volume: 13(5) Pages: R146
• [Presentation] 膝関節半月板の部位特性に関する研究 (2014)
  • Author(s): 張項凱, 青山朋樹, 伊藤明良, 山口将希, 長井桃子, 飯島広貴, 太治野純一, 黒木裕士
  • Organizer: 第27回日本軟骨代謝学会
  • Place of Presentation: 京都市
  • Year and Date: 20140228-29
• [Presentation] ラットOAモデルに対する運動の軟骨変性予防効果 (2014)
  • Author(s): 飯島広貴, 青山朋樹, 伊藤明良, 太治野純一, 長井桃子, 張項凱, 山口将希, 黒木裕士
  • Organizer: 第27回日本軟骨代謝学会
  • Place of Presentation: 京都市
  • Year and Date: 20140228-29
• [Presentation] 膝関節拘縮後の軟骨基質変化‐超微細構造からの検討- (2014)
  • Author(s): 長井桃子, 伊藤明良, 太治野純一, 飯島広貴, 山口将希, 張項凱, 青山朋樹, 秋山治彦, 黒木裕士
  • Organizer: 第27回日本軟骨代謝学会
  • Place of Presentation: 京都市
  • Year and Date: 20140228-29
• [Presentation] 温度環境は軟骨外基質能に影響を与える-ヒト軟骨細胞を用いたin vitro研究- (2014)
  • Author(s): 伊藤明良, 青山朋樹, 長井桃子, 太治野純一, 山口将希, 飯島広貴, 張項凱, 秋山治彦, 黒木裕士
  • Organizer: 第27回日本軟骨代謝学会
  • Place of Presentation: 京都市
  • Year and Date: 20140228-29
• [Presentation] 関節軟骨の最表層は3層の構造で構成される (2013)
  • Author(s): 青山朋樹, 藤岡瑠音, 高桑徹也
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉市
  • Year and Date: 20131017-18
• [Presentation] 軟骨細胞に対する長期温熱刺激の安全性と軟骨基質生合成へ与える影響の検討 (2013)
  • Author(s): 伊藤明良, 青山朋樹, 長井桃子, 山口将希, 飯島弘貴, 太治野純一, 張項凱, 井上大輔, 広瀬太希, 秋山治彦, 黒木裕士
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 20130524-26
• [Presentation] 膝半月板被覆部の軟骨・骨複合体は構造的に脆弱である (2013)
  • Author(s): 飯島弘貴, 青山朋樹, 伊藤明良, 太治野純一, 張項凱, 長井桃子, 山口将希, 広瀬太希, 井上大輔, 秋山治彦, 黒木裕士
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 20130524-26
• [Presentation] 膝関節不動が関節軟骨におけるCD44発現に及ぼす影響 (2013)
  • Author(s): 長井桃子, 伊藤明良, 山口将希, 飯島弘貴, 太治野純一, 張項凱, 井上大輔, 広瀬太希, 青山朋樹, 黒木裕士
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 20130524-26
• [Presentation] 寒冷刺激が変形性膝関節症ラットの関節軟骨に及ぼす影響 (2013)
  • Author(s): 山口将希, 伊藤明良, 長井桃子, 張項凱, 飯島弘貴, 太治野純一, 青山朋樹, 秋山治彦, 広瀬太希, 井上大輔, 黒木裕士
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 20130524-26
• [Presentation] Culturing temperature affects chondrocyte differentiation and extracellular matrix formation (2013)
  • Author(s): A Ito, T Aoyama, J Tajino, M Nagai, S Yamaguchi, H Iijima, X Zhang, H Akiyama, H Kuroki
  • Organizer: 2013 World Congress on Osteoarthritis
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20130418-21
• [Presentation] Changes on the expression of CD44 in immobilized knee in rats (2013)
  • Author(s): M Nagai, A Ito, X Zhang, S Yamaguchi, H Iijima, J Tajino, T Aoyama, H Kuroki
  • Organizer: 2013 World Congress on Osteoarthritis
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20130418-21
• [Presentation] Is cartilage and subchondral bone covered by menisci weak? (2013)
  • Author(s): H Iijima, T Aoyama, A Ito, J Tajino, M Nagai, X Zhang, S Yamaguchi, H Akiyama, H Kuroki
  • Organizer: 2013 World Congress on Osteoarthritis
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20130418-21
• [Presentation] 半月板被覆部軟骨は脆弱であるのか (2013)
  • Author(s): 飯島弘貴, 青山朋樹, 伊藤明良, 太治野純一, 長井桃子, 張項凱, 山口将希, 秋山治彦, 黒木裕士
  • Organizer: 第26回日本軟骨代謝学会
  • Place of Presentation: 大阪市
  • Year and Date: 20130301-02
• [Presentation] 温度環境が軟骨細胞外基質形成に与える影響 (2013)
  • Author(s): 伊藤明良, 青山朋樹, 長井桃子, 山口将希, 飯島弘貴, 張項凱, 太治野純一, 秋山治彦, 黒木裕士
  • Organizer: 第26回日本軟骨代謝学会
  • Place of Presentation: 大阪市
  • Year and Date: 20130301-02
• [Presentation] The effect of exercise levels on biomarker in a knee osteoarthritis model of rats (2012)
  • Author(s): Yamaguchi S, Kuroki H, Aoyama T, Ito A, Zhang K, Tazino Z, Nagai M, Iijima H
  • Organizer: the 1st Joint Conference for the partnership between JPTA and KPTA
  • Place of Presentation: Nagasaki city, Japan
  • Year and Date: 20121117-18
• [Presentation] Analyses of cartilage superficial layer using immunohistochemical staining (2012)
  • Author(s): Fujioka R, Aoyama T, Takakuwa T
  • Organizer: 012 World congress on osteoarthritis
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20120426-29
• [Presentation] IL-1βにより惹起されたMMP13 mRNA 発現亢進に対する低出力超音波パルスの即時的効果 (2012)
  • Author(s): 伊藤明良, 山口将希, 張 項凱, 青山朋樹, 秋山治彦, 黒木裕士
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋市
  • Year and Date: 20120309-10
• [Presentation] 免疫組織化学的手法を用いた関節軟骨最表層の観察 (2012)
  • Author(s): 藤岡瑠音, 青山朋樹, 高桑徹也
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: 名古屋市
  • Year and Date: 20120309-10
• [Presentation] Low-intensity pulsed ultrasound downregulates the messenger RNA expression of the matrix metalloproteinases on an articular cartilage explants model (2011)
  • Author(s): Akira Ito, Tomoki Aoyama, Hiroto Mitsui, Makoto Ishibashi, Shoki Yamaguchi, Xiang Kai Zhang, Hiroshi Kuroki
  • Organizer: 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, CA
  • Year and Date: 20110915-18
• [Presentation] Analysis of meniscus using fourier transform infrared imaging spectroscopy (2011)
  • Author(s): Hiroshi Kuroki, Kouji Tsuchimoto, Mikiko Kobayashi-Miura, Tomoki Aoyama, Akira Ito, Koujiro Hshimoto, Makoto Ishibashi, Shoki Yamaguchi, Xiang Kai Zhang
  • Organizer: 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, CA
  • Year and Date: 20110915-18
• [Remarks]
  • URL: http://humanalysis-square.com/