2013 Fiscal Year Final Research Report
Identification of the urinary biomarker to predect hypertension in young adults
| Project/Area Number |
23300243
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tohoku University |
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Principal Investigator |
HIDA Wataru 東北大学, 高等教育開発推進センター, 名誉教授 (10142944)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Takefumi 東北大学, 医学系研究科, 准教授 (40375001)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 尿中バイオマーカー / 高血圧 / 生活習慣病 / アンジオテンシノージェン / 腎内レニン・アンジオテンシン系 |
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| Research Abstract |
The present study was desiged to identify the urinary biomarker to predict the pathogenesis of hypertension. We enrolled incoming freshmen of our university and adults who have taken health checkup in Kawasaki town in Miyagi in 2011. Urinary excertion of angiotensinogen (AGT), inflammation markers, oxidative stress markers and carbonyl compounds and serum AGT, inflammation markers levels were analyzed. The present study determined the association between blood pressure and uriary AGT and inflammation markers excretion in young obese adults. From multiple linear regression analysis, urinary AGT excretion was significantly associated with blood pressure in adults.
This study suggested that urinary AGT excretion would predicte the pathogenesis of hypertension inyoung obase adults.
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[Journal Article] Role of renin-angiotensin system, oxidative stress and inflammation to the blood pressure control in young subjects2012
Author(s)
Sato Emiko, Mori Takefumi, Nakamichi Yoshimi, Fujiwara Mutsuko, Oba Ikuko, Tannno Mizuho, Ogawa Susumu, Kinouchi Yoshitaka, Sato Hiroshi, Hida Wataru, Ito Sadayoshi
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Journal Title
XVI International Congress on Nutrition and Metabolism in Renal Disease ICRNM
Pages: 53-59
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