2013 Fiscal Year Final Research Report
Role of histidine in glucose metabolism
| Project/Area Number |
23300274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kanazawa University |
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Principal Investigator |
INOUE Hiroshi 金沢大学, 脳・肝インターフェースメディシン研究センター, 教授 (50397832)
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| Co-Investigator(Kenkyū-buntansha) |
HAGA Sanae 北海道大学, 保健科学研究院, 博士研究員 (60706505)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アミノ酸 / 肝糖脂質代謝 / 食生活 |
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| Research Abstract |
We previously revealed that hepatic STAT3 decreases the expression of hepatic gluconeogenic enzymes and suppresses hepatic glucose production. Here, we show that increased plasma histidine caused by protein intake resulted in hepatic STAT3 activation. Intravenous and intracerebroventricular administration of histidine also activated hepatic STAT3 and augmented the suppression of hepatic glucose production by insulin. Inhibition of hepatic glucose production by histidine was blocked by inhibiting histamine H1receptors in the central nervous system. Therefore, histidine activates hepatic STAT3 and suppresses hepatic glucose production via central histamine action. In the central nervous system, the mechanisms of histidine and insulin are independent, but have additive inhibitory effects on hepatic glucose prodcution. This suggests that central histidine-mediated suppressive action on hepatic glucose production is a potential target for the treatment of type 2 diabetes.
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[Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action2013
Author(s)
Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H
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Journal Title
Diabetes
Volume: 62(7)
Pages: 2266-77
Peer Reviewed
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[Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR432013
Author(s)
Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
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Journal Title
Nat Commun
Volume: 4
Pages: 1829
Peer Reviewed
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[Journal Article] Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice2013
Author(s)
Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H, Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T
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Journal Title
Diabetologia
Volume: 56(6)
Pages: 1383-93
Peer Reviewed
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[Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013
Author(s)
Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
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Journal Title
Diabetologia
Volume: 56(5)
Pages: 1088-97
Peer Reviewed
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[Journal Article] CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status2012
Author(s)
Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto KI, Ginsberg HN, Mukaida N, Kaneko S, Ota T
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Journal Title
Diabetes
Volume: 61(7)
Pages: 1680-90
Peer Reviewed
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[Journal Article] CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis2012
Author(s)
Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M
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Journal Title
Nat Med
Volume: 18(4)
Pages: 612-7
Peer Reviewed
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[Journal Article] Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation2012
Author(s)
Kimura K, Yamada T, Matusmoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H
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Journal Title
Diabetes
Volume: 61(1)
Pages: 61-73
Peer Reviewed
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[Journal Article] Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC12011
Author(s)
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y
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Journal Title
PLoS One
Volume: 6(8)
Pages: e23238
Peer Reviewed
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