2013 Fiscal Year Final Research Report
Study on risk reduction of lifestyle-related diseases due to modulations of digestion/absorption capability of carbohydrates.
| Project/Area Number |
23300276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Kazuki 山梨大学, 大学院・医学工学総合研究部, 准教授 (80423838)
ICHIKAWA Yoko 静岡県立大学, 食品栄養科学部, 准教授 (50269495)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 食後高血糖 / 小腸 / バイオマーカー / 遺伝子発現 / 慢性炎症 |
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| Research Abstract |
The hypothesis that suppression of postprandial hyperglycemia due to retardation of digestion/absorption of carbohydrates leads to reductions of chronic inflammation and resulting lifestyle-related disease risk, was examined in animal models and human subjects.
Feeding a diet containing resistant starch (RS) or alpha-glucosidase inhibitor (miglitol) in type 2 diabetes model rats caused a reduction in postprandial glycemic levels, and it led to suppression of inflammation-related gene expressions in adipose tissue and peripheral leukocytes, along with reduced expression of cell adhesion molecules in aorta tissue. The postprandial hyperglycemia-associated inflammation was suppressed by consumption of anti-oxidation food factors such as EGCG. Cross-sectional studies of healthy subjects showed that a higher rate of eating is associated with plasma IL-1b levels, suggesting that IL-1b is a marker for inflammation, presumably caused by hyperglycemia.
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Research Products
(43 results)
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[Journal Article] Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients2014
Author(s)
Imai, C., Saito, M., Mochizuki, K., Fuchigami, M., Goda, T., and Osonoi, T
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Journal Title
Metabolism
Volume: 63
Pages: 746-753
Peer Reviewed
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[Journal Article] PlasmasE-selectin level positively correlated with neutrophil count and diastolic blood pressure in Japanese men2013
Author(s)
Mochizuki, K., Inoue, S., Miyauchi, R., Misaki, Y., Shimada, M., Kasezawa, N., Tohyama, K., and Goda, T
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Journal Title
J. Nutr. Sci. Vitaminol
Volume: 59
Pages: 447-453
Peer Reviewed
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[Journal Article] A higher rate of eating is associated with higher circulating interleukin-1b concentrations in Japanese men not being treated for metabolic diseases2012
Author(s)
Mochizuki, K., Misaki, Y., Miyauchi, R., Takabe, S., Shimada, M., Kuriki, K., Ichikawa, Y., Goda, T
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Journal Title
Nutrition
Volume: 28
Pages: 978-983
Peer Reviewed
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[Journal Article] Associations between leukocyte counts and cardiovascular disease risk factors in apparently healthy Japanese men2012
Author(s)
Mochizuki, K., Miyauchi, R., Misaki, Y., Kasezawa, N., Tohyama, K., and Goda, T
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Journal Title
J. Nutr. Sci. Vitaminol
Volume: 58
Pages: 181-186
Peer Reviewed
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[Journal Article] Associations between markers of liver injury and cytokine markers for insulin sensitivity and inflammation in middle-aged Japanese men not being treated for metabolic diseases2011
Author(s)
Mochizuki, K., Misaki, Y., Miyauchi, R., Takabe, S., Shimada, M., Ichikawa, Y., Goda, T
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Journal Title
J. Nutr. Sci. Vitaminol
Volume: 57
Pages: 409-417
Peer Reviewed
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