2013 Fiscal Year Final Research Report
Development of in vivo function and safety screening method for food ingrdient
| Project/Area Number |
23300279
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Ariake National College of Technology |
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Principal Investigator |
TOMINAGA NOBUAKI 有明工業高等専門学校, その他部局等, 教授 (30227631)
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| Co-Investigator(Kenkyū-buntansha) |
有薗 幸司 熊本県立大学, 環境共生, 教授 (70128148)
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| Co-Investigator(Renkei-kenkyūsha) |
松野 哲也 有明工業高等専門学校, 電子情報, 教授 (80243921)
山口 明美 有明工業高等専門学校, 支援センター, 技術職員 (90399262)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 食品 / 生理活性 / マイクロアレイ / 機能性 / 解析・評価 |
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| Research Abstract |
In this study, we developed a novel evaluation method of functional material and food safety screening using Caenorhabditis elegans as model organism and synthetic medium. We could make a synthetic medium which was made from given ingredients and could cultivate C. elegans from egg to adult. Then we evaluated flavonoids quercetin, rutin which are known as anti-oxidative property. Growth rate of C. elegans was increased by addition of these materials to medium. Demands of trace elements were also determined. Depletion of Copper or Zinc was induced significant loss of fecundity. Moreover we evaluated the effects of insulin and vanadium. The results indicated that the toxicity of vanadium was stimulated by an addition of insulin. We could show that this screening method developed by this study was well work for not only screened for function of food ingredient but also for evaluation of complex effects of food and medicine.
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