2013 Fiscal Year Final Research Report
Development of education movies demonstrating real-time biophysical phenomena by two photon laser microscopy
| Project/Area Number |
23300284
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Science education
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| Research Institution | Mie University |
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Principal Investigator |
MIZOGUCHI Akira 三重大学, 医学(系)研究科(研究院), 教授 (90181916)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 2光子レーザー顕微鏡 / 生体内細胞観察 / GFPマウス / iPS細胞 / 病気の可視化 / 治療効果の可視化 / 生命科学実感教材の開発 / 超早期癌診断・治療 |
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| Research Abstract |
I have engaged in development of education movies demonstrating real-time biophysical phenomena in vivo and in vitro by two photon laser microscopy. Two photon laser microscopy is a new method based on two photon excitation which generates new photons inside the animal body for visualizing real-time images of cells. These real-time movies demonstrating dynamic phenomena occurring inside our body probably enhance the understanding of students studying biological science. In this study I have obtained the real-time images of normal cells in gastrointestinal tracts, liver, pancreas, kidney, brain, and vessels. I have also observed the real-time images of cancer cells in intestines, which gives me an opportunity to develop a novel method to identify very small cancers at the ultra-early stages. The new method has been submitted as an international patent under the financial support from JST. The education movies obtained in this study will be opened in a free internet service.
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[Journal Article] In vivo optical pathology of paclitaxel efficacy on the peritoneal metastatic xenograft model of gastric cancer using two-photon laser scanning microscopy2014
Author(s)
Shimura T, Tanaka K, Toiyama Y, Okigami M, Ide S, Kitajima T, Kondo S, Saigusa S, Ohi M, Araki T, Inoue Y, Uchida K, Mohri Y, Mizoguchi A, Kusunoki M
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Journal Title
Gastric Cancer
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration2012
Author(s)
Wang S, Watanabe T, Matsuzawa K, Katsumi K, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Matsuda M, Ginsberg MH, Collard JG, Kaibuchi K
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Journal Title
J Cell Biol
Volume: 199(2)
Pages: 331-345
DOI
Peer Reviewed
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[Journal Article] In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy2012
Author(s)
Tanaka K, Okigami M, Toiyama Y, Morimoto Y, Matsushita K, Kawamura M, Hashimoto K, Saigusa S, Okugawa Y, Inoue Y, Uchida K, Araki T, Mohri Y, Mizoguchi A, Kusunoki M
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Journal Title
Oncol Rep
Volume: 28(5)
Pages: 1822-1830
DOI
Peer Reviewed
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[Journal Article] In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy2012
Author(s)
Tanaka K, Morimoto Y, Toiyama Y, Matsushita K, Kawamura M, Koike Y, Okugawa Y, Inoue Y, Uchida K, Araki T, Mizoguchi A, Kusunoki M
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Journal Title
J Oncol
Volume: 2012
Pages: 265487
DOI
Peer Reviewed
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[Journal Article] Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse2011
Author(s)
Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K
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Journal Title
Hum Mol Genet
Volume: 20(23)
Pages: 4666-4683
DOI
Peer Reviewed
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[Patent(Industrial Property Rights)] 生体染色法2014
Inventor(s)
溝口 明, 木村一志, 田中光司, 藤原武志, 王 淑杰, 崔 煌植
Industrial Property Rights Holder
三重大学
Industrial Property Rights Type
国際特許
Industrial Property Number
AC552-PCT
Filing Date
2014-03-28
Overseas
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