2013 Fiscal Year Final Research Report
Gastric cancer: a mouse model and epigenetic statuses of blood in mice and humans
| Project/Area Number |
23300342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YUASA Yasuhito 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (80111558)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 胃がん / マウスモデル / DNA / メチル化 / エピジェネティクス / 治療薬 / マイクロRNA |
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| Research Abstract |
Diffuse-type gastric cancer (DGC) exhibits rapid disease progression and a poor prognosis. We have reported an E-cadherin/p53 double conditional knockout (DCKO) mouse line as the first genetically engineered one, which recapitulates human DGC morphologically and molecularly. Recently, we have also established mouse DGC (MDGC) cell lines from primary tumors and lymph node metastases of the DCKO mice.
We identified four circulating microRNAs that could accurately detect DGC at an early stage utilizing the DCKO mice, and indicated that one of them might have potential as a non-invasive biomarker in young human DGC patients. The results from in vivo and in vitro assays using the DCKO mice and the MDGC cell lines demonstrate that epigenetic alterations may play significant roles in diffuse-type gastric carcinogenesis, and support to develop a relevant therapeutic strategy in human DGC.
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[Journal Article] CD49f^<high> cells retain sphere-forming and tumor-initiating activities in human gastric tumors2013
Author(s)
Fukamachi H, Seol HS, Shimada S, Funasaka C, Baba K, Kim JH, Park YS, Kawachi H, Yook JH, Eishi Y, Kojima K, Kim WH, Jang SJ, Yuasa Y
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Journal Title
PLoS One
Volume: 8
Pages: e72438
DOI
Peer Reviewed
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages2013
Author(s)
Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M
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Journal Title
Cancer Res
Volume: 73
Pages: 3019-3028
DOI
Peer Reviewed
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[Journal Article] Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk2012
Author(s)
Yuasa Y, Nagasaki H, Oze I, Akiyama Y, Yoshida S, Shitara K, Ito S, Hosono S, Watanabe M, Ito H, Tanaka H, Kang DH, Pan K-F, You W-C, Matsuo K
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Journal Title
Int. J. Cancer
Volume: 131
Pages: 2596-2603
Peer Reviewed
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