2014 Fiscal Year Final Research Report
Development of extensive analyses methods of tumor and cell differentiation related miRNA using
| Project/Area Number |
23300357
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Chuo University |
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Principal Investigator |
TAGUCHI Y-h. 中央大学, 理工学部, 教授 (30206932)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Jun 東北大学, 東北メディカル・メガバンク機構, 教授 (00281684)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | microRNA / promoter methylation / histone modificatiuon / gene expression |
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| Outline of Final Research Achievements |
We proposed MiRaGE (MiRNA Ranking by Gene Expression) that infer miRNA inhibition of target mRNAs using mRNA expression profiles and demonstrated its abilities. Replacing gene expression with promoter methylation or histone modification, we found the miRNA-target-specific promoter methylation and histone modifications.
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| Free Research Field |
Gene expression/epigenetic profile analyses
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