2013 Fiscal Year Final Research Report
Radiation target and mutagenesis in intestinal tumors
| Project/Area Number |
23310036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Niigata University |
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Principal Investigator |
KOMINAMI Ryo 新潟大学, 医歯(薬)学総合研究科, 客員研究員 (40133615)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Yukio 新潟大学, 医歯学系, 准教授 (30142029)
KATSURAGI Yoshinori 新潟大学, 医歯学系, 助教 (60401759)
OBATA Miki 新潟大学, 医歯学系, 教務職員 (00420307)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 電離放射線 / 発がん / 幹細胞 / 大腸がん / 胸腺リンパ腫 / Bcl11b |
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| Research Abstract |
Attenuated expression of Bcl11b in Lgr5-expressing intestinal crypt cells promoted regeneration of intestinal epithelial cells after the radiation-induced injury in Lgr5-Cre; Bcl11bflox/+ mice. This suggests that the origin of cells in intestinal tumors, which are enhanced by loss of one Bcl11b allele in Apcmin/+ mice, is Lgr5-expressing cells. It was also demonstrated that Bcl11b functions as a subunit of SWI/SNF chromatin remodeling complex and down-regulates transcription of Wnt/beta-catenin target genes such as c-jun. This suggests that Bcl11b impairment instigates intestinal tumor development at least in part through deregulation of beta-catenin pathway.
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Research Products
(15 results)
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[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors2013
Author(s)
Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R
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Journal Title
Mech Dev
Volume: 130
Pages: 482-492
Peer Reviewed
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[Journal Article] Compound Heterozygosity of the Functionally Null Cdh23v-ngt and Hypomorphic Cdh23ahl/i Alleles Leads to Early-onset Progressive Hearing Loss in Mice2013
Author(s)
Miyasaka Y, Suzuki S, Ohshiba Y, Watanabe K, Sagara Y, Yasuda SP, Matsuoka K, Shitara H, Yonekawa H, Kominami R, Kikkawa Y
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Journal Title
Exp Anim
Volume: 62
Pages: 333-346
Peer Reviewed
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[Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012
Author(s)
Go, R, Takizawa, K, Hirose, S, Katsuragi, Y, Aoyagi, Y, Mishima, Y, and Kominami, R
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Journal Title
Leuk Res
Volume: 36
Pages: 1035-1040
Peer Reviewed
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