2013 Fiscal Year Final Research Report
Functional analysis of a histone methyltransferase in colorectal cancer by comprehensive genome analysis
| Project/Area Number |
23310137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKENOUE Tsuneo 東京大学, 医科学研究所, 准教授 (80396712)
YAMAGUCHI Rui 東京大学, 東京大学, 講師 (90380675)
YAMAGUCHI Kiyoshi 東京大学, 医科学研究所, 助教 (50466843)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 疾患関連遺伝子 |
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| Research Abstract |
Expression profile analysis using colon cancer cells treated with SMYD3-specific siRNA identified a total of 1543 genes (entities) that were significantly upregulated by SMYD3. Subsequent in silico analysis using MetaGP revealed that these genes are potentially controlled by 126 transcription factors. Combined with the data of ChIP on chip analysis using anti-SMYD3 antibody, we identified 110 candidates of target genes of SMYD3. In addition, gene ontology and gene set enrichment analyses elucidated that elevated SMYD3 expression is associated with cell cycle control. These data suggest that SMYD3 plays a crucial role in proliferation of cancer cells and that inhibition of its function should be a rational strategy to treat human cancers.
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Research Products
(21 results)
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[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014
Author(s)
Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
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Journal Title
PLoS ONE
Volume: 9
Pages: e85750
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[Journal Article] Early detection of metachronous bile duct cancer in Lynch syndrome : report of a case2013
Author(s)
Shigeyasu K, Tanakaya K, Nagasaka T, Aoki H,Fujiwara T, Sugano K, Ishikawa H, Yoshida T, Moriya Y, Furukawa Y, Goel A, Takeuchi H.
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Journal Title
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[Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells2013
Author(s)
Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Michizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 110(8)
Pages: 3023-3028
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[Journal Article] Quantitative PCR detection of CEP110-FGFR1 fusion gene in a patient with 8p11 syndrome2013
Author(s)
Yamamoto S, Ebihara Y, Mochizuki S, Kawakita T,Kato S, Ooi J, Tojo A, Yusa N, Furukawa Y, Oyaizu N, Watanabe J, Sato K, Kimura F, and Tsuji K
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Journal Title
Leukemia & Lymphoma
Volume: 54(9)
Pages: 2068-9
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[Journal Article] MRG-binding protein contributes to colorectal cancer development2011
Author(s)
Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
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Journal Title
Cancer Sci
Volume: 102(8)
Pages: 1486-92
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