2013 Fiscal Year Final Research Report
Analysis of the network constructed by dosage balanced genes in yeast
| Project/Area Number |
23310140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
System genome science
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| Research Institution | Okayama University |
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Principal Investigator |
MORIYA Hisao 岡山大学, その他部局等, 准教授 (60500808)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Takashi 東北大学, 大学院・生命科学研究科, 准教授 (20443442)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 遺伝子ネットワーク / タンパク質ネットワーク / 量感受性遺伝子 / 量的均衡遺伝子 / 酵母 / ゲノム |
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| Research Abstract |
Dosage balanced gene (DBG) is a gene whose expression is balanced against more than two genes, and the perturbation of the balance causes cellular dysfunction. Using a genetic method designated "genetic tug-of-war", we have been trying to identify "dosage sensitive genes" whose minor overexpression cause cellular dysfunction. In this study, we proceeded this analysis, and identified 115 dosage sensitive genes in the budding yeast genome. We further identified 13 dosage-balanced interactions. This study is the first example for the systematic identification of dosage sensitive genes in a organism's genome, and for the identification of multiple dosage balanced genes at a time.
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Research Products
(26 results)
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[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012
Author(s)
Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H, Watanabe K
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Journal Title
Chembiochem
Volume: 13(6)
Pages: 846-54
DOI
Peer Reviewed
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[Remarks] 雑誌論文⑥のプレスリリースが,山陽新聞(2012.12.29),日本経済新聞(2013.1.7)に掲載された.マイナビニュース(2012.12.28)で紹介された.
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[Remarks] 雑誌論文⑨のプレスリリースが,山陽新聞(2011.12.7)に掲載された.NHK 岡山放送(2011.12.8)のニュースで紹介された
