2013 Fiscal Year Final Research Report
Synthesis of biologically acitive natural product cyclodepsipeptides and their analogues
| Project/Area Number |
23310145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
DOI TAKAYUKI 東北大学, 薬学研究科(研究院), 教授 (90212076)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生物活性分子の合成 / 環状デプシペプチド / ペプチドミメティクス / 生物活性天然物 / 固相合成 / 非天然型アミノ酸 / マクロラクタム化 |
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| Research Abstract |
Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. We have demonstrated (1) design and synthesis of peptide mimetics of apratoxin A and total synthesis of apratoxin C, (2) synthesis of water soluble telomestatin analogues that is as potent as telomestatin in telomerase inhibitory activity, (3) combinatorial synthesis of destruxin E analogues and their SAR study, (4) design and synthesis of peptide mimetics of beauveriolide III and synthesis of photoaffinity probes of beauveriolide III.
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[Journal Article] Design and synthesis of 2-phenyl-1,4-dioxa-spiro [4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A2013
Author(s)
S. Fuse, K. Inaba, M. Takagi, M. Tanaka, T. Hirokawa, K. Johmoto, H. Uekusa, K. Shin-ya, T. Takahashi, T. Doi
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Journal Title
Eur. J. Med. Chem
Volume: 66
Pages: 180-184
DOI
Peer Reviewed
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[Journal Article] Comprehensive Predictions of Target Proteins Based on Protein-Chemical Interaction Using Virtual Screening and Experimental Verifications2012
Author(s)
H. Kobayashi, H. Harada, M. Nakamura, Y. Futamura, A. Ito, M. Yoshida, S. Iemura, K. Shin-ya, T. Doi, T. Takahashi, T. Natsume, M. Imoto, Y. Sakakibara
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Journal Title
BMC Chem. Biol
Volume: 12(2)
DOI
Peer Reviewed
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