A living body action and the application to medical treatment by inhalation of atmospheric pressure plasma flow

2013 Fiscal Year Final Research Report

• Project/Area Number: 23340180
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plasma science
• Research Institution: Tokyo City University
• Principal Investigator: MORI Akira 東京都市大学, 工学部, 教授 (60219996)
• Co-Investigator(Kenkyū-buntansha): HIRATA Takamichi 東京都市大学, 工学部, 教授 (80260420)
• Co-Investigator(Renkei-kenkyūsha): KUDO Yoshiki 広島大学, 医学部, 教授 (80241082) ; IWASHITA Mitsutoshi 杏林大学, 医学部, 教授 (30124936)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: プラズマ吸入

Research Abstract

We carried out the experiments about the direct inhalationto animal model (pulmonary hypertension of goat or mini-pig and neonatal hypoxia/ischemia rat). The use of inhalated plasma, generated by the atmospheric-pressure plasmas reactor, resulted in increased saturation pulse oxygen in the pulmonary hypertension of animals. Additionally, the blood pressure decreased during plasma inhalation. Nitric oxide (NO) concentrations in the arteries increased after 20 seconds of plasma inhalation, reaching a maximum value at about 160 s and gradually decreased. The NO generated by this device was highly concentrated, reaching a maximum of approximately 10nmol. Moreover, the infarct areas treated with plasma inhalation (15days, 90sec inhalation/ day) were evaluated in the neonatal hypoxic/ischemic rat model. Each plasma inhalation-treated group (n=6) demonstrated significant increae of new bood vessels compared with the no treated group (n=6).

Research Products

• [Journal Article] Treatment of cardiac disease by inhalation of atmospheric pressure plasma (2014)
  • Author(s): Chihiro Tsutsui1, Minjoo Lee, Genu Takahashi, Shigeru Murata, Takamichi Hirata, Takao Kanai, and Akira Mori
  • Journal Title: Japanese Journal of Applied Physics Volume: 54
• [Journal Article] Healing Burns Using Atmospheric Pressure Plasma Irradiation (2013)
  • Author(s): T. Hirata, Takumi Kishimoto, Chihiro Tsutsui, Takao Kanai, Akira Mori
  • Journal Title: Japanese Journal of Applied Physics Volume: 53 Pages: 010302
• [Journal Article] The effect of plasma inhalation for the cardiovascular system by rat (2013)
  • Author(s): S. Murata, A. Mori, M. Watada, T Hirata, C. Tsutsui, T. A. Kondo, G Takahashi
  • Journal Title: S. Murata, A. Mori, M. Watada, T Hirata, C. Tsutsui, T. A. Kondo, G Takahashi Volume: Vol. 21 Pages: 260-265
• [Journal Article] NOセンサーを利用したプラズマ吸入療法中の血中NO濃度変化の検討 (2013)
  • Author(s): 高橋玄宇, 村田茂, 和多田雅哉, 山崎慶子, 米川侑希, 平田孝道,筒 井千尋, 森晃
  • Journal Title: ClinicalEngineerring Volume: Vol.24 Pages: 714-715
• [Journal Article] プラズマ照射治療に使用するプラズマ吸入がラットの下行大動脈圧に与える影響の検討 (2012)
  • Author(s): 村田茂, 森晃, 和多田雅哉, 平田孝道, 筒井千尋, 山崎慶子, 米川侑希
  • Journal Title: Clinical Engineerring Volume: Vol23 Pages: 652-653
• [Journal Article] マイクロスポット大気圧プラズマ源による細胞の活性化 (2011)
  • Author(s): 筒井千尋, 平田孝道, 秋谷昌宏, 田口亮, 小町俊文, 岸本拓巳, 秋谷昌宏, 山本俊昭森晃
  • Journal Title: 静電気学会雑 Volume: Vol.35 Pages: 20-24
• [Journal Article] Fat liquefaction of adipose tissue using atmospheric-pressure plasma irradiation (2011)
  • Author(s): T. Hirata, C. Tsutsui, T. Kishimoto, A. Mori, M. Akiya, T. Yamamoto, and A. Taguchi
  • Journal Title: Japanese Journal of Applied Physics Volume: Vol.50,No.8 Pages: 080217-1-080217-3
• [Journal Article] Measurement of Contractile Activity in Small Animal's Digestive Organ by Carbon Nanotube-Based Force Transducer (2011)
  • Author(s): T. Hirata, N. Takeda, C. Tsutsui, K. Koike, Y. Shimatani, T. Sakai, A Mori, and A. Taguchi
  • Journal Title: Japanese Journal of Applied Physics Volume: Vol. 50, No.3 Pages: 030210,-1-030210-3
• [Journal Article] Tissue and Cell Activation Using Micro-Spot Atmospheric Pressure Plasma Source (2011)
  • Author(s): C. Tsutsui, T. Hirata, T. Komachi, T. Kishimoto, A. Mori, M. Akiya, T. Yamamoto, and A. Taguchi
  • Journal Title: Journal of Institute of Electrostatic Japan Volume: 35 Pages: 20-24
• [Presentation] Attempt of Relaxation Therapy of Lung, Brain, and Heart Disorders by Plasma-Ion Inhalation (2013)
  • Author(s): T. Hirata, C. Tsutsui, and A. Mori
  • Organizer: 26th Symposium on Plasma Science for Materials
  • Year and Date: 20130000
  • Invited
• [Presentation] Disease Treatments Specializing in the Regenerative Medicine Using Biomedical Plasma Techniques (2013)
  • Author(s): T. Hirata, C. Tsutsui, and A. Mori
  • Organizer: JSAP-MRS Joint Symposia for 2013 JSAP Autumn Meeting
  • Year and Date: 20130000
  • Invited
• [Presentation] Uteroplacental circulation and maternal abdominal aortic stiffness in normal and compromised pregnancy : its therapy by the atmospheric pressure plasma (2012)
  • Author(s): A. Mori, S. Murata, T. Hirata, Y. Kudo, M. Iwashita
  • Organizer: International Federation of Placenta Associations Meeting
  • Year and Date: 20120000
• [Book] 先端医療を支える工学ー生体医工学への誘い (2014)
  • Total Pages: 153