2013 Fiscal Year Final Research Report
Elucidation of the chemical processes of biological reactions based on the design of novel nano-sized reaction environments
| Project/Area Number |
23350015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
GOTO Kei 東京工業大学, 理工学研究科, 教授 (70262144)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 有機化学 / 酵素モデル / 活性中間体 / レドックス制御 / ナノサイズ分子 |
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| Research Abstract |
Novel nano-sized molecular cavities with a dendrimer-type framework were developed for modeling reaction environments in the active site of enzymes that enable the stabilization highly reactive intermediates. By utilizing the novel model compounds, several highly reactive species otherwise very unstable in artificial systems were successfully synthesized and their reactivities were elucidated. These results contribute to the experimental demonstration of the hypothetically proposed chemical processes involved in the redox regulation and signaling.
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Research Products
(49 results)
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[Journal Article] Chloro-(η6-p-cymene)-{3-[3,5-bis(2,6dimethylphenyl)-1,2-phenylene]-1-(2,6,2"6"-tetramethyl-1,1':3',1"-terphenyl-5'-yl)imid azol-2-ylidene}-ruthenium(II) benzene disolvate2014
Author(s)
Sase, S.; Ikehara, Y.; Goto, K.Domoto, Y.; Sase, S.; Goto, K.
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Journal Title
Acta Crystallogr., Sect. E
Volume: 70
Pages: m394
Peer Reviewed
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[Journal Article] Copper(I)-Dioxygen Reactivity in a Sterically Demanding Tripodal Tetradentate tren Ligand: Formation and Reactivity of a Mononuclear Copper(II) End-On Superoxo Complex2012
Author(s)
Kobayashi, Y.; Ohkubo, K.; Nomura, T.; Kubo, M.; Fujieda, N.; Sugimoto, H.;Fukuzumi, S.; Goto, K.; Ogura, T.; Itoh, S.
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Journal Title
Eur. J. Inorg. Chem.
Pages: 4574-4578
Peer Reviewed
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