2013 Fiscal Year Final Research Report
Precise Characterization of Macromolecular Assemblies for Quality Control of Biomaterials
| Project/Area Number |
23350055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Takahiro 大阪大学, 理学(系)研究科(研究院), 教授 (10196248)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIDZUME Akihito 大阪大学, 大学院・理学研究科, 准教授 (70294147)
TERAO Ken 大阪大学, 大学院・理学研究科, 講師 (60334132)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 自己組織化高分子 / 感熱応答性高分子 / ポリイオンコンプレックス / ブロック共重合体 / ミセル / 相分離 |
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| Research Abstract |
Macromolecular assemblies are utilized as biomaterials like drug delivery system, nano-carrier, or bio-sensor. Precise characterization of macromolecular assemblies is essential to control the quality of those biomaterials. In this study, we have established the method for characterizing assemblies of thermoresponsive block copolymers and polyelectrolyte complexes in solution. Simultaneous micellization and phase separation took place in three thermoresponsive block copolymers investigated, all of which were weakly segregated and weakly amphiphilic block copolymers. Both micelles and concentrated-phase droplets in the solutions were characterized by small-angle X-ray scattering. The number of net charges and total charges (or the aggregation number) per the polyelectrolyte complex were determined by static and electrophoretic light scattering methods for four combinations of two polyanions and two polycations in aqueous solution to compare with proposed complex formation mechanism.
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