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2013 Fiscal Year Final Research Report

Study on evaluation methods of heating mechanism and distribution in cultured cell of magnetic nanoparticles

Research Project

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Project/Area Number 23360179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionYokohama National University

Principal Investigator

TAKEMURA Yasushi  横浜国立大学, 工学研究院, 教授 (30251763)

Co-Investigator(Kenkyū-buntansha) YAMADA Tsutomu  国立大学法人横浜国立大学, 大学院・工学研究院, 助手 (70251767)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords磁性ナノ粒子 / がん温熱治療 / 磁気緩和
Research Abstract

Hyperthermia, thermal treatment for cancer, is expected to reduce scar and side effects. A heating method using magnetic nanoparticles delivered to tumor is promising. Magnetic nanoparticles are heated by an external magnetic field. In order to heat tumor selectively, study on magnetic nanoparticles heated effectively by a magnetic field with low intensity is significant. In order to analyze the heating mechanism of magnetic nanoparticles, evaluation methods for heating property and distribution in cultured cell are developed.

  • Research Products

    (31 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (24 results)

  • [Journal Article] Physical Parameters to Enhance AC Magnetically Induced Heating Power of Ferrite Nanoparticles for Hyperthermia in Nanomedicine2013

    • Author(s)
      Minhong Jeun, Sanghoon Lee, Yu Jeong Kim, Hwa Yeon Jo, Ki Ho Park, Sun Ha Paek, Yasushi Takemura, and Seongtae Bae
    • Journal Title

      IEEE Transactions on Nanotechnology

      Volume: Vol. 12 , Issue 3 Pages: 314-322

    • DOI

      10.1109/TNANO.2013.2247414

    • Peer Reviewed
  • [Journal Article] Transfection efficiency influenced by aggregation of DNA/polyethylenimine max/magnetic nanoparticle complexes2013

    • Author(s)
      Satoshi Ota, Yoshiyuki Takahashi, Asahi Tomitaka, Tsutomu Yamada, Daisuke Kami, Masatoshi Watanabe, Yasushi Takemura
    • Journal Title

      Journal of Nanoparticle Research

      Volume: 15, 1653 Pages: 1-12

    • DOI

      10.1007/s11051-013-1653-y

    • Peer Reviewed
  • [Journal Article] Self-heating temperature and ac hysteresis of magnetic iron oxide nanoparticles and their dependence on secondary particle size2013

    • Author(s)
      K. Nakamura, K.Ueda, A. Tomitaka, T.Yamada, Y. Takemura
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: vol. 49, no. 1 Pages: 240-243

    • DOI

      10.1109/TMAG.2012.2226567

    • Peer Reviewed
  • [Journal Article] 液中分散された磁性ナノ粒子の高周波励磁における磁気緩和2012

    • Author(s)
      上田浩司, 冨高あさひ, 山田努, 竹村泰司
    • Journal Title

      電気学会論文誌A (基礎・材料・共通部門誌)

      Volume: Vol. 132, No. 10 Pages: 813-817

    • DOI

      10.1541/ieejfms.132.813

    • Peer Reviewed
  • [Journal Article] Magnetic nanoparticle hyperthermia using Pluronic-coated Fe_3O_4 nanoparticles : an in vitro study2012

    • Author(s)
      Asahi Tomitaka, Tsutomu Yamada and Yasushi Takemura
    • Journal Title

      Journal of Nanomaterials

      Volume: Volume 2012, Article ID 480626 Pages: 5

    • DOI

      10.1155/2012/480626

    • Peer Reviewed
  • [Journal Article] Heat dissipation and magnetic properties of surface-coated Fe_3O_4 nanoparticles for biomedical applications2012

    • Author(s)
      Asahi Tomitaka, Koji Ueda, Tsutomu Yamada, Yasushi Takemura
    • Journal Title

      Journal of Magnetism and Magnetic Materials

      Volume: Volume 324, Issue 21 Pages: 3437-3442

    • DOI

      10.1016/j.jmmm.2012.02.060

    • Peer Reviewed
  • [Journal Article] Physical limits of pure superparamagnetic Fe_3O_4 nanoparticles for a local hyperthermia agent in nanomedicine2012

    • Author(s)
      Minhong Jeun, Sanghoon Lee, Jae Kyeong Kang, Asahi Tomitaka, Keon Wook Kang, Young Il Kim, Yasushi Takemura, Kyung-Won Chung, Jiyeon Kwak and Seongtae Bae
    • Journal Title

      Applied Physics Letters

      Volume: 100, 092406 Pages: 1-4

    • DOI

      10.1063/1.3689751

    • Peer Reviewed
  • [Presentation] Evaluation of hysteresis loop and magnetic relaxation time of magnetic nanoparticles under alternating magnetic field2014

    • Author(s)
      Satoshi Ota, Kosuke Nakamura, Asahi Tomitaka, Tsutomu Yamada, Yasushi Takemura
    • Organizer
      4th International Workshop on Magnetic Particle Imaging (IWMPI 2014)
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2014-03-28
  • [Presentation] Combination of magnetic hyperthermia, antibody, and cryptotanshinon enhancing the effect of cancer therapy2013

    • Author(s)
      S. Ota, N. Yamazaki, A. Tomitaka, T. Yamada, Y. Takemura
    • Organizer
      The 3rd International Symposium on Advanced Magnetic Materials and Applications (ISAMMA 2013)
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      20130721-25
  • [Presentation] Evaluation of magnetic nanoparticles for biomedical applications2013

    • Author(s)
      Yasushi Takemura
    • Organizer
      2013 EMN (Energy Materials and Nanotechnology) Fall Meeting, INVITED, Abstracts Book of 2013 EMN Fall Meeting
    • Place of Presentation
      Orland, USA
    • Year and Date
      2013-11-07
  • [Presentation] ポリエチレンイミンおよびその修飾磁性ナノ粒子の異なる細胞内局在の評価2013

    • Author(s)
      大多哲史, 冨高あさひ, 山田努, 大介, 五條理志, 渡邉昌俊, 竹村泰司
    • Organizer
      第51回日本人工臓器学会大会(共催 : 第5回国際人工臓器学術大会,第21回国際ロータリー血液ポンプ学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-27
  • [Presentation] Transfection of polyethylenimine and its coated magnetic nanoparticles by different pathways in cytoplasm2013

    • Author(s)
      S. Ota, A. Tomitaka, T. Yamada, D. Kami, M. Watanabe, Y. Takemura
    • Organizer
      Biomedical Engineering Society, Annual Meeting 2013, P-Th-A- 200
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-09-26
  • [Presentation] 磁性ナノ粒子を用いた遺伝子導入法とその導入効率における交流磁場の影響2013

    • Author(s)
      清野貴史, 大多哲史, 高橋慶行, 冨高あさひ, 上大介, 渡邉昌俊, 山田努, 竹村泰司
    • Organizer
      電気学会 基礎・材料・共通部門大会,12-P-15
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
  • [Presentation] 抗体を結合させた磁性ナノ粒子を用いたがん温熱治療の検討2013

    • Author(s)
      赤池正平, 大多哲史, 山崎直哉, 冨高あさひ, 山田努, 竹村泰司
    • Organizer
      平成25年 電気学会 基礎・材料・共通部門大会,12-P-23
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
  • [Presentation] ポリエチレンイミン修飾磁性ナノ粒子/DNA 複合体の凝集に依存した遺伝子導入効率2013

    • Author(s)
      大多哲史, 冨高あさひ, 山田努, 上大介, 渡邉昌俊, 竹村泰司
    • Organizer
      第37回日本磁気学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-09-05
  • [Presentation] 磁性ナノ粒子ハイパーサーミアと抗体を組み合わせたがん治療効果2013

    • Author(s)
      大多哲史, 山崎直哉, 冨高あさひ, 山田努, 竹村泰司
    • Organizer
      第37回日本磁気学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-09-05
  • [Presentation] Intensity and frequency of exciting magnetic field for biomedical applications2013

    • Author(s)
      Yasushi Takemura
    • Organizer
      第37回日本磁気学会学術講演会, シンポジウム「Generation and utilization of a magnetic field for medical applications」
    • Place of Presentation
      Symposium organizer, 札幌
    • Year and Date
      2013-09-04
  • [Presentation] 磁気ハイパーサーミアの発熱体と磁場条件2013

    • Author(s)
      竹村泰司
    • Organizer
      日本ハイパーサーミア学会第30回大会 シンポジウム「磁性体を用いたハイパーサーミアの現状と未来」
    • Place of Presentation
      横浜
    • Year and Date
      2013-08-31
  • [Presentation] 機能化磁性ナノ粒子を用いたがん温熱治療とアポトーシス誘導2013

    • Author(s)
      大多哲史, 竹村泰司
    • Organizer
      12th Conference for BioSignal and Medicine (CBSM2013)
    • Place of Presentation
      バイオシステムダイナミクスと医療デバイス理工学,山梨
    • Year and Date
      2013-07-13
  • [Presentation] Magnetic nanoparticles for biomedical applications - from cancer therapy to gene delivery -2013

    • Author(s)
      Yasushi Takemura
    • Organizer
      2nd International Congress on Advanced Materials, E7, INVITED
    • Place of Presentation
      Zhenjiang, China
    • Year and Date
      2013-05-17
  • [Presentation] Induced apoptosis in combination therapy of antibody and hyperthermia using Cryptotanshinone and antibody/magnetic nanoparticle complex2013

    • Author(s)
      Naoya Yamazaki, Asahi Tomitaka, Tsutomu Yamada, Yasushi Takemura
    • Organizer
      30th Annual Meeting of the Society for Thermal Medicine
    • Place of Presentation
      Aruba
    • Year and Date
      2013-04-19
  • [Presentation] Aggregation of DNA/PEI max/magnetic nanoparticle complexes inducing decline of transfection efficiency2013

    • Author(s)
      S. Ota, A. Tomitaka, T. Yamada, D. Kami, M. Watanabe, Y. Takemura
    • Organizer
      The 11th International Conference on Ferrites (ICF 11)
    • Place of Presentation
      Okinawa
    • Year and Date
      2013-04-17
  • [Presentation] Heating methods and materials for hyperthermia - from medical equipment to nanotechnology2012

    • Author(s)
      Yasushi Takemura
    • Organizer
      2012 EMN (Energy Materials and Nanotechnology) Fall Meeting, B21, INVITED
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2012-12-01
  • [Presentation] Combination therapy of antibody and hyperthermia using magnetic nanoparticles2012

    • Author(s)
      Yasushi Takemura
    • Organizer
      The 3rd Annual World Congress of NanoMedicine-2012, 1-2-1, INVITED
    • Place of Presentation
      Shenzhen, China
    • Year and Date
      2012-11-02
  • [Presentation] New functionality of magnetic nanoparticles in biomedical applications - from gene delivery to combination therapy with antibody2012

    • Author(s)
      Yasushi Takemura
    • Organizer
      The 2nd International Conference of the Asia Union of Magnetics Societies (ICAUMS2012), 2pC-1, INVITED
    • Place of Presentation
      Nara
    • Year and Date
      2012-10-02
  • [Presentation] Influence of surface coating on magnetic and self-heating properties of Fe_3O_4 nanoparticles and in vitro experiment for hyperthermia2012

    • Author(s)
      Asahi Tomitaka, Tsutomu Yamada and Yasushi Takemura
    • Organizer
      9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
    • Place of Presentation
      Minneapolis, USA
    • Year and Date
      2012-05-23
  • [Presentation] Self-heating temperature and ac hysteresis of magnetite nanoparticles and their dependence on secondary particle size2012

    • Author(s)
      Kosuke Nakamura, Koji Ueda, Asahi Tomitaka, Tsutomu Yamada and Yasushi Takemura
    • Organizer
      9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
    • Place of Presentation
      Minneapolis, USA
    • Year and Date
      2012-05-23
  • [Presentation] 交流励磁したフェライト系磁性ナノ粒子の磁気緩和2011

    • Author(s)
      上田浩司, 冨高あさひ, 山田努, 竹村泰司
    • Organizer
      電気学会マグネティックス研究会
    • Place of Presentation
      仙台
    • Year and Date
      2011-11-25
  • [Presentation] Evaluation of self-heating property of magnetic nanoparticle coated by dispersant2011

    • Author(s)
      T. Kitame, K. Ueda, H. Kobayashi, A. Tomitaka, T. Yamada and Y. Takemura
    • Organizer
      Asia-Pacific Interdisciplinary Research Conference 2011 (AP-IRC 2011), 18PP-36
    • Place of Presentation
      Toyohashi
    • Year and Date
      2011-11-18
  • [Presentation] Thermal therapy for cancer : from magnetic nanoparticles to excitation by MRI2011

    • Author(s)
      Yasushi Takemura
    • Organizer
      BIT Life Sciences' 2nd Annual NanoMedicine-2011 Conference, Session 318 : Practical Instrument and Analytical Technology in Nanostructure Characterization, INVITED, Digests Book pp. 129
    • Place of Presentation
      Shenzhen, China
    • Year and Date
      2011-11-03
  • [Presentation] 癌温熱治療用磁性ナノ粒子の高周波励磁下での緩和機構の評価2011

    • Author(s)
      上田浩司, 小林宏紀, 冨高あさひ, 山田努, 竹村泰司
    • Organizer
      2011年第35回日本磁気学会学術講演会
    • Place of Presentation
      新潟
    • Year and Date
      2011-09-27

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Published: 2015-06-25  

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