2013 Fiscal Year Final Research Report
Analysis and control of membrane raft dynamics.
| Project/Area Number |
23360366
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
TAKAGI MASAHIRO 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (00183434)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Tsutomu 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 准教授 (40432140)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 細胞模倣膜 / ラフト / リポソーム / ダイナミクス |
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| Research Abstract |
We characterized the membrane phase separation structures in oxidized cholesterol(Chol)-containing systems. 7-kotocholesterol(7-keto) and 7beta-hydoroxycholesterol(7beta).
Especially, the phase separation was strongly enhanced in Chol/7keto system. On the other hand, the phase separation was suppressed in 7beta-containing system. Our results showed that the hydrophilic interactions among lipids and cholesterols play important roles in formation and stability of domain structures.
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Research Products
(48 results)
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[Journal Article] Antimicrobial activity and mechanism of action of a novel cationic α-helical dodecapeptide, a partial sequence of cyanate lyase from rice2013
Author(s)
N. Takei, N. Takahashi, T. Takayanagi, A. Ikeda, M. Takagi, T. Hamada, E. Saitoh, A. Ochiai, T. Tanaka, M. Taniguchi
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Journal Title
Peptides
Volume: 42
Pages: 55-62
Peer Reviewed
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[Presentation] 脂質酸化物含有細胞サイズリポソ-ムの相分離構造2013
Author(s)
依田毅, 乾 航, Phan Huong T. T.,下川直史, Mun ' delanjii Vestergaard 濱田勉, 高木昌宏
Organizer
平成 25年度北陸地区講演会と研究発表会
Place of Presentation
石川県ハイテク交流センター
Year and Date
2013-11-22
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[Presentation] 酸化コレステロール含有生体模倣膜のドメイン形成2013
Author(s)
乾 航, Phan Huong Thi Thanh ,依田 毅, 下川 直史, M.C.Vestergaard , 濱田勉, 高木昌宏
Organizer
第7回バイオ関連化学シンポジウム
Place of Presentation
名古屋大学東山キャンパス 豊田講堂・野依学術交流館
Year and Date
2013-09-29
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