2013 Fiscal Year Final Research Report
Application of protein cationization techniques for cancer immunotherapy
| Project/Area Number |
23360370
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKIMI Kazuhiro 東京大学, 医学部付属病院, 准教授 (80273358)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | タンパク質工学 / 化学修飾 / バイオテクノロジー / 腫瘍免疫 / 診断薬 / ワクチン |
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| Research Abstract |
This study aimed development of chemical protein cationization techniques for cancer antigens. Since most of cancer antigen proteins are flexible and unstable, solubilization with protein cationization techniques were useful methodology to prepare water-soluble and full-length cancer antigens. Using these cationized antigens, antigen antibodies for cancer antigens raised in cancer patients were successfully detected with a highly sensitive assay. Combining these developed techniques and enhanced cancer antigen production resource, we have successfully developed tools for cancer immunotherapy.
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[Journal Article] Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene2014
Author(s)
Masakiyo Sakaguchi, Masami Watanabe, Rie Kinoshita, Haruki Kaku, Hideo Ueki, Junichiro Futami, Hitoshi Murata, Yusuke Inoue, Shun-Ai Li, Peng Huang, Endy Widya Putranto, I. Made, Winarsa Ruma, Yasutomo Nasu, Hiromi Kumon, Nam-ho Huh
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