2013 Fiscal Year Final Research Report
Development of completely autologous aortic valves by a novel concept of regenerative medicine
| Project/Area Number |
23360374
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NAKAYAMA Yasuhide 独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)
UECHI Masami 日本大学, 生物資源科学部, 教授 (90296426)
KANDA Keiichi 京都府立医科大学, 医学研究科, 講師 (60295649)
WATANABE Taiji 京都府立医科大学, 医学研究科, 助教 (20448723)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 再生医療 / 生体内組織形成 / バイオリアクター / バイオプロセス / バイオバルブ / バイオチューブ / セルフリーデバイス / 体内組織工学 |
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| Research Abstract |
Tissue-engineering techniques may play a prominent role in the future development of cardiovascular replacements. Research designed to create in vitro tissue-engineered tissues has focused on the scaffold materials, culturing of cells, and its condition. As a feasible, regenerative medicine approach, this study developed cell-free devices for the preparation of completely autologous in vivo tissue-engineered cardiovascular tissues without any artificial scaffolds by using of in-body tissue architecture technology. The tissue formation process was enhanced successfully by design or photo engineering approaches. The biocompatibility was obtained by material engineering approach. We used a 3D printer to produce cell-free devices. The clinical feasibility of the valve-shaped tissues obtained from the devices was evaluated by their implanting in goats after evaluating their function and durability in vitro.
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[Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014
Author(s)
Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] In vivo evaluation of an in-body, tissue-engineered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model2013
Author(s)
Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y
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Journal Title
J Artif Organs
Volume: 25
Pages: 176-184
DOI
Peer Reviewed
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[Journal Article] Water-soluble argatroban for antithrpmbogenic surface coating of tissue-engineered cardiovascular tissues2011
Author(s)
Nakayama Y, Yamaoka S, Yamanami M, Fujiwara M, Uechi M, Takamizawa K, Ishibashi-Ueda H, Nakamichi M, Uchida K, Watanabe T, Kanda K, Yaku H.
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: 99
Pages: 420-430
DOI
Peer Reviewed
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