2013 Fiscal Year Final Research Report
Genetic analyses of the molecular and neuronal mechanisms for the regulation of forgetting
| Project/Area Number |
23370002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHIHARA Takeshi 九州大学, 理学(系)研究科(研究院), 教授 (10249948)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Manabi 九州大学, 理学研究院, 助教 (70359933)
SAWATARI Etsuko 九州大学, 基幹教育院, 助教 (60456605)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 行動遺伝 / 線虫 / 記憶 / カルシウムイメージング |
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| Research Abstract |
Animals show a variety of behavioral plasticity, in which animals change their behavior dependent on their environments. Those behavioral plasticity must be sustained for an appropriate time to survive. However, the neuronal and molecular mechanisms of forgetting of memories are poorly understood. Therefore, we studied on the forgetting of olfactory adaptation in C. elegans as a model for the behavioral plasticity. We found that the forgetting of the olfactory adaptation is actively regulated by the environmental conditions before and after conditioning. In addition, we identified a pair of neurons that secrete signals for the forgetting of the olfactory adaption in other sensory neurons. These results suggested that the forgetting is actively regulated by the neuronal communications.
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Research Products
(13 results)
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[Journal Article] Forgetting in C. elegans is accelerageted by neuronal communication via the TIR-1/JNK-1 pathway2013
Author(s)
Inoue, A. Sawatari, E., Hisamoto, N., Kitazono, T. Teramoto, T., Fujiwara, M., Matsumoto, K., Ishihara, T
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Journal Title
Cell Reports
Volume: 3
Pages: 808-819
DOI
Peer Reviewed
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[Journal Article] An expanded palette of genetically encoded Ca^<²+> indicators2011
Author(s)
Zhao, Y., Araki, S., Wu, J., Teramoto, T., Chang, Y.F., Nakano, M., Abdelfattah, A.S., Fujiwara, M., Ishihara, T., Nagai, T
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Journal Title
Campbell, R.E. Science
Volume: 333
Pages: 1888-1891
DOI
Peer Reviewed
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