Analysis of atypical small GTPases involved in membrane dynamics

2014 Fiscal Year Final Research Report

• Project/Area Number: 23370083
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: The University of Tokyo
• Principal Investigator: KONTANI Kenji 東京大学, 薬学研究科(研究院), 准教授 (30302615)
• Co-Investigator(Kenkyū-buntansha): FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 助教 (20422389) ; SAITO Kota 東京大学, 大学院薬学系研究科, 助教 (60549632)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 低分子量Gタンパク質 / メンブラントラフィック / オルガネラ / 線虫

Outline of Final Research Achievements

In this study, we analyzed some atypical small GTPases and found that 1) ARL8 is involved in phagosome-lysosome fusion and required for efficient removal of apoptotic cells; 2) both the N-terminal palmitoylation and the C-terminal RVxP motif of Arl13b are required for the ciliary localization of Arl13b; 3) Di-Ras2 activity may be regulated via interaction with SmgGDS; 4) C. elegans Di-Ras homolog functions as a positive regulator for acetylcholine release from neuronal cells.

Free Research Field

生物化学