2014 Fiscal Year Final Research Report
Analysis of atypical small GTPases involved in membrane dynamics
Project/Area Number |
23370083
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | The University of Tokyo |
Principal Investigator |
KONTANI Kenji 東京大学, 薬学研究科(研究院), 准教授 (30302615)
|
Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 助教 (20422389)
SAITO Kota 東京大学, 大学院薬学系研究科, 助教 (60549632)
|
Project Period (FY) |
2011-04-01 – 2015-03-31
|
Keywords | 低分子量Gタンパク質 / メンブラントラフィック / オルガネラ / 線虫 |
Outline of Final Research Achievements |
In this study, we analyzed some atypical small GTPases and found that 1) ARL8 is involved in phagosome-lysosome fusion and required for efficient removal of apoptotic cells; 2) both the N-terminal palmitoylation and the C-terminal RVxP motif of Arl13b are required for the ciliary localization of Arl13b; 3) Di-Ras2 activity may be regulated via interaction with SmgGDS; 4) C. elegans Di-Ras homolog functions as a positive regulator for acetylcholine release from neuronal cells.
|
Free Research Field |
生物化学
|