2015 Fiscal Year Final Research Report
The regulation of dynamics of coronary and epicardial progenitor cells
Project/Area Number |
23370092
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Kyoto Sangyo University |
Principal Investigator |
ISHII Yasuo 京都産業大学, 総合生命科学部, 研究員 (20582430)
|
Project Period (FY) |
2011-04-01 – 2016-03-31
|
Keywords | 心臓 / 冠動脈 / 心外膜 / ニワトリ |
Outline of Final Research Achievements |
Coronary vessels supply the oxygen and nutrients to the entire heart muscle. Early embryonic heart, however, is avascular. The development of coronary vessels depends on a recruitment of an extracardiac rudiment called the proepicardium (PE). The PE, a villous protrusion that forms on the coelomic surface of the liver, protrudes in the pericardial cavity to fuse to a beating heart and cover its entire surface, forming the epicardium. What regulates the PE fusion and how epicardial cells later contribute to coronary vascular development still remain unclear. Our experimental approaches using the avian model revealed that (a) contact-dependent tissue interactions, mediated by the Eph/ephrin signaling, promotes the PE fusion, and that (b) both the epicardial EMT and coronary vascular development is promoted by epicardial misimpression of vascular endothelial growth factor-A.
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Free Research Field |
発生生物学
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