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2013 Fiscal Year Final Research Report

Evolution of Eye as sensory organ

Research Project

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Project/Area Number 23370098
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionNational Institute of Genetics

Principal Investigator

IKEO KAZUHO  国立遺伝学研究所, 生命情報研究センター, 准教授 (20249949)

Project Period (FY) 2011-04-01 – 2014-03-31
Keywords分子進化
Research Abstract

To understand the process and origin of various eyes, I conducted comparative evolutionary study by using next generation sequence technology. For the purpose, I took two different types of Jellyfish with and without eye and also dinoflagellate with different types of lens eye. RNA-seq by next generation sequence technology performed collection of gene expression profiles of the species. The visual pigment of dinoflagellate showed the similarity with bacterial pigment and it suggests the origin of their eye-like structure related to bacterial origin. The other side, the result of jellyfish showed the molecules related their lens development evolutionaliry related with our genes, thus, jellyfish already gain molecular system for lens conformation before establishing nervous system. Now, we still continue more fine analysis of the data.

  • Research Products

    (4 results)

All 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] Longitudinal clinical course of three Japanese patients with Leber congenital amaurosis/early-onset retinal dystrophy with RDH12 mutation2014

    • Author(s)
      Kuniyoshi K, Sakuramoto H, Yoshitake K, Abe K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T
    • Journal Title

      Doc Ophthalmol

      Volume: 128(3) Pages: 219-28

    • Peer Reviewed
  • [Journal Article] Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene2014

    • Author(s)
      Katagiri S, Akahori M, Hayashi T, Yoshitake K, Gekka T, Ikeo K, Tsuneoka H, Iwata T
    • Journal Title

      Doc Ophthalmol

      Volume: 128(3) Pages: 211-7

    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alströ m syndrome2013

    • Author(s)
      Katagiri S, Yoshitake K, Akahori M, Hayashi T, Furuno M, Nishino J, Ikeo K, Tsuneoka H, Iwata T
    • Journal Title

      Mol Vis

      Volume: 19 Pages: 2393-406

    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profile of epiretinal membranes obtained from eyes with proliferative vitreoretinopathy to that of secondary epiretinal membranes2013

    • Author(s)
      Asato R, Yoshida S, Ogura A, Nakama T, Ishikawa K, Nakao S, Sassa Y, Enaida H, Oshima Y, Ikeo K, Gojobori T, Kono T, Ishibashi T
    • Journal Title

      PLoS One

      Volume: 8(1) Pages: e54191

    • Peer Reviewed

URL: 

Published: 2015-06-25  

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