Influence of vitamin K status to physiological polymorphism of bone metabolism

2014 Fiscal Year Final Research Report

• Project/Area Number: 23370105
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)
• Co-Investigator(Kenkyū-buntansha): OSAKI Makoto 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20380959) ; HONDA Sumihisa 長崎大学, 医歯薬学総合研究科(保健学系), 教授 (90244053) ; ABE Yasuyo 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90372771)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: ビタミンK / 骨代謝 / 骨粗鬆症 / 生理的多型性 / 運動機能 / 踵骨超音波法

Outline of Final Research Achievements

We studied Vitamin K status using serum undercarboxylated osteocalcin (ucOC), and examined the association of ucOC with low bone mass contributing to fragile fracture, adjusting for age, body size (body mass index: BMI) and physical performance (5-times chair stand time). Subjects were 1127 community-dwelling people (461 men and 666 women). We conducted multiple linear regression analysis. In men, bone mass (stiffness index) was negatively associated with age. BMI had a borderline association. No association was found between bone mass and ucOC or 5-times chair stand time. In women, bone mass (stiffness index) was negatively associated with ucOC, age and 5-times chair stand time, and was positively associated with BMI.

Free Research Field

応用人類学