2013 Fiscal Year Final Research Report
Biological Localization and Functionality of Allenic Carotenoids
| Project/Area Number |
23380068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIYASHITA Kazuo 北海道大学, 大学院水産科学研究院, 教授 (10182015)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSOKAWA Masashi 北海道大学, 大学院・水産科学研究院, 准教授 (10241374)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アレンカロテノイド / 抗肥満 / 抗糖尿病 / フコキサンチン / エネルギー代謝 |
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| Research Abstract |
In the present study, molecular mechanisms were made clear for the anti-obesity effect of fucoxanthin by the induction of UCP1 in abdominal WAT. The anti-obesity effect of fucoxanthin was suggested to be due to its specific structure that contains two carotenoid end rings of the polyene chromophore containing allenic bond and OH and epoxy groups. Therefore, other allenic carotenoids or scission products from fucoxanthin could not show such activities as found in fucoxanthin. Fucoxanthin also improves insulin resistance and decreases blood glucose level through the regulation of adipocytokine secretions from the abdominal WAT. Another important molecular mechanism for the improvement of glucose utilization by fucoxanthin will be glucose transporter 4 (GLUT4) up-regulation and promotion of its translocation to cell membrane from cytosol.
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