2013 Fiscal Year Final Research Report
Studies on the development of anti-obesity synbiotics
| Project/Area Number |
23380069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SONOYAMA Kei 北海道大学, (連合)農学研究科(研究院), 准教授 (90241364)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 肥満 / プロバイオティクス / プレバイオティクス / 腸内細菌 / 炎症 / エキソソーム |
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| Research Abstract |
We previously showed that Lactobacillus plantarum No.14 reduces obesity in mice, whereas the cellular and molecular mechanisms remain unknown. The present study demonstrated that L. plantarum No.14 reduces obesity, adiopose tissue inflammation, and insulin resistance in type 2 deiabetic mice. In addition, we showed that exosomes isolated from the serum of mice fed L. plantarum No.14 reduce the production of inflammatory cytokines in peritoneal exudate cells and murine macrophage cell line RAW264.7. The results suggest that exosomes play a role in cell-to-cell communication in terms of anti-inflammatory action of L. plantarum No.14.
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