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2013 Fiscal Year Final Research Report

Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods

Research Project

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Project/Area Number 23380073
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

HACHIMURA SATOSHI  東京大学, 農学生命科学研究科, 准教授 (40238019)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Jiro  九州大学, 農学研究院, 准教授 (40217930)
TAKAHASHI Yoshimasa  国立感染症研究所, 免疫部, 室長 (60311403)
HOSONO Akira  日本大学, 生物資源科学部, 准教授 (70328706)
Research Collaborator NAKAJIMA Haruyo (ADACHI Haruyo)  東京大学, 農学生命科学研究科, 特任研究員 (20595962)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords腸管免疫系 / 腸内共生菌 / 機能性食品 / IgA抗体 / TLR / 制御性T細胞 / 樹状細胞 / 経口免疫寛容
Research Abstract

In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.

  • Research Products

    (23 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results) Presentation (7 results)

  • [Journal Article] Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice2014

    • Author(s)
      Park, J., Miyakawa, T., Shiokawa, A., Nakajima-Adachi, H., Tanokura, M., Hachimura, S
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice2014

    • Author(s)
      Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., Adachi, Y., Fukudome, S., Takahashi, Y., Hachimura, S
    • Journal Title

      PLoS ONE

      Volume: 9, e86416

    • DOI

      10.1371/journal.pone.00864

    • Peer Reviewed
  • [Journal Article] Generation of memory B cells inside and outside germinal centers2014

    • Author(s)
      Takemori, T., Kaji, T., Takahashi, Y., Shimoda, M., Rajewsky, K
    • Journal Title

      Eur. J. Immunol

      Volume: 44 Pages: 1258-1264

    • DOI

      10.1002/eji.201343716

  • [Journal Article] Enhancement of intestinal immune function in mice by β-D-glucan from aureobasidium pullulans ADK-342013

    • Author(s)
      Tanioka, A., Tanabe, K., Hosono, A., Kawakami, H., Kaminogawa, S., Tsubaki, K., Hachimura, S
    • Journal Title

      Scand. J. Immunol

      Volume: 78 Pages: 61-8

    • DOI

      10.1111/sji.12067

    • Peer Reviewed
  • [Journal Article] Both unmutated and mutated memory B cells accumulate mutations and renew antibody repertoire optimally adopted to antigen upon re-exposure2013

    • Author(s)
      Kaji, T., Furukawa, K., Ishige, A., Toyokura, I., Takahashi, Y., Shimoda, M., Takemori, T
    • Journal Title

      Int. Immunol

      Volume: 25 Pages: 683-695

    • DOI

      10.1093/intimm/dxt030

    • Peer Reviewed
  • [Journal Article] Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-alpha-dependent apoptosis2013

    • Author(s)
      Ato, M., Takahashi, Y., Fujii, H., Hashimoto, S., Kaji, T., Itamura, S., Horiuchi, Y., Arakawa, Y., Tashiro, M., Takemori, T
    • Journal Title

      Vaccine

      Volume: 31 Pages: 2184-2190

    • DOI

      10.1016/j.vaccine.2013.02.016

    • Peer Reviewed
  • [Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine : Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA^<+> B cells2013

    • Author(s)
      Yanagibashi,T., Hosono, A., Oyama, A., Tsuda, M., Suzuki, A., Hachimura, S., Takahashi, Y., Momose, Y., Itoh, K., Hirayama, K., Takahashi, K., Kaminogawa, S
    • Journal Title

      Immunobiology

      Volume: 218 Pages: 645-651

    • DOI

      10.1016/j.imbio.2012.07.033

    • Peer Reviewed
  • [Journal Article] Distinct cellular pathways select germ-line encoded and somatically mutated antibodies into immunological memory2012

    • Author(s)
      Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K., Takemori, T
    • Journal Title

      J. Exp. Med

      Volume: 209 Pages: 2079-2097

    • DOI

      10.1084/jem.20120127

    • Peer Reviewed
  • [Journal Article] 腸管におけるIgA 産生とCD3^<->IL-2R^<+>細胞2012

    • Author(s)
      八村敏志
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 387-390

  • [Journal Article] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012

    • Author(s)
      Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachimura, S., Kurosaki, T., Kobayashi, K
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 2485-2490

    • DOI

      10.1073/pnas.1115369109

    • Peer Reviewed
  • [Journal Article] Commensal bacteria promote migration of mast cells into the intestine2011

    • Author(s)
      Kunii, J., Takahashi, K., Kasakura, K., Tsuda, M., Nakano, K., Hosono, A., Kaminogawa, S
    • Journal Title

      Immunobiology

      Volume: 216 Pages: 692-697

    • DOI

      10.1016/j.imbio.2010.10.007

    • Peer Reviewed
  • [Journal Article] Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-12011

    • Author(s)
      Sugi, Y., Takahashi, K., Nakano, K., Hosono, A., Kaminogawa, S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 412 Pages: 704-709

    • DOI

      10.1016/j.bbrc.2011.08.035

    • Peer Reviewed
  • [Journal Article] Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells2011

    • Author(s)
      Takahashi, K., Sugi, Y., Nakano, K., Tsuda, M., Kurihara, K., Hosono, A., Kaminogawa, S
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 35755-35762

    • DOI

      10.1074/jbc.M111.271007

    • Peer Reviewed
  • [Journal Article] Gut as a target for functional food2011

    • Author(s)
      Shimizu, M., Hachimura, S
    • Journal Title

      Trend. Food Sci. Technol

      Volume: 22 Pages: 646-650

    • DOI

      10.1016/j.tifs.2011.06.002

  • [Journal Article] ウイルス感染局所における記憶B 細胞応答2011

    • Author(s)
      高橋宜聖, 小野寺大志, 小林和夫
    • Journal Title

      実験医学増刊

      Volume: 29 Pages: 81-86

  • [Journal Article] 腸管自然免疫系と腸内細菌

    • Author(s)
      八村敏志
    • Journal Title

      臨床栄養

      Volume: 120 Pages: 685-685-688

  • [Presentation] 加齢による免疫機能変化と食品による調節2014

    • Author(s)
      八村敏志, 田之倉優
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学(神奈川)
    • Year and Date
      2014-03-30
  • [Presentation] 経口免疫寛容において誘導されるCD62L^<high/int>CD44^<int> およびCD62L^<low>CD44^<high>T 細胞の機能解析2014

    • Author(s)
      芝原恭子ら
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学(神奈川)
    • Year and Date
      2014-03-28
  • [Presentation] 腸内細菌による腸管免疫細胞の制御 : アレルギー抑制に関連して2014

    • Author(s)
      八村敏志
    • Organizer
      第17回日本病態栄養学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-01-12
  • [Presentation] Suppression of TLR9-induced response by TLR2 pathway in Peyer's patch dendritic cells2013

    • Author(s)
      KOTAKI Ryutaro ら
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2013-12-12
  • [Presentation] 粘膜組織に存在するIgA産生促進CD3-IL-2R+細胞のユニークな性状2012

    • Author(s)
      横井勇祐ら
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2012-03-24
  • [Presentation] 腸内共生菌のIgA 産生に関わる免疫担当細胞に対する作用2011

    • Author(s)
      石井俊祐ら
    • Organizer
      日本食品免疫学会2011年度大会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2011-10-18
  • [Presentation] 複数のTLR 刺激を受けたパイエル板樹状細胞における応答抑制の解析2011

    • Author(s)
      上滝隆太郎ら
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2011-03-25

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Published: 2015-06-25  

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