2013 Fiscal Year Final Research Report
Studies on comprehensive physiological functions of novel exogenous neuromodulating peptides
| Project/Area Number |
23380076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
OHINATA Kousaku 京都大学, (連合)農学研究科(研究院), 准教授 (00361147)
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| Co-Investigator(Renkei-kenkyūsha) |
URADE Yoshihiro 大阪バイオサイエンス研究所, 研究部長 (10201360)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ペプチド / 情動調節 / 睡眠 / 食欲 / エネルギー代謝 |
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| Research Abstract |
We investigated interaction between low-molecular weight peptides and the nervous system. We found novel anxiolytic-like peptides released from food proteins by gastrointestinal proteases, based on structure-activity relationship of potent anxiolytic peptides. The food-derived peptides may be one of exogenous neuromodulating factors. We also found that low-molecular peptides with neuromodulating activities sometimes exhibited sleep inducting activity, changed food intake, and modulated energy metabolism.
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[Journal Article] Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice2012
Author(s)
Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K
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Journal Title
Mol Nutr Food Res
Volume: 56(8)
Pages: 1315-23
Peer Reviewed
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[Journal Article] Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice2012
Author(s)
Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302(4)
Pages: E433-40
Peer Reviewed
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[Journal Article] β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS2 receptor via activation of dopamine D1 receptor in mice2011
Author(s)
Hou IC, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K
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Journal Title
J Neurochem
Volume: 119(4)
Pages: 785-90
Peer Reviewed
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