2013 Fiscal Year Final Research Report

Protectivity of extensive infections by a bacterial outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Research Project

Project/Area Number	23380111
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	General fisheries
Research Institution	Ehime University
Principal Investigator	KAWAI Kenji 愛媛大学, (連合)農学研究科(研究院), 教授 (60127925)
Co-Investigator(Kenkyū-buntansha)	OSHIMA Syun-ichirou 高知大学, 教育研究部総合科学系, 教授 (80325406) IMAJOH Masayuki 高知大学, 教育研究部自然科学系, 講師 (20565741)
Project Period (FY)	2011-04-01 – 2014-03-31
Keywords	魚病 / ワクチン / 外膜タンパク質 / GAPDH
Research Abstract	Protective effects of an outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from a bacterium Edwardsiella tarada against other difficult fish diseases, pseudotuberculosis and nocardiosis, was investigated using yellowtail (Seriola quinqueradiata). The fish immunized with GAPDH did not show enough level of protection against both diseases. However, it showed the growth inhibition of infecting Nocardia inside fish body, increased the production of immunoglobulin, and stimulated some immuno-competent genes. Fish pathogenic Mycobacterium sp. was found to be a model bacterium that may show pathogenicity to humans.

(3 results)