2013 Fiscal Year Final Research Report
Protectivity of extensive infections by a bacterial outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
| Project/Area Number |
23380111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Ehime University |
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Principal Investigator |
KAWAI Kenji 愛媛大学, (連合)農学研究科(研究院), 教授 (60127925)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Syun-ichirou 高知大学, 教育研究部総合科学系, 教授 (80325406)
IMAJOH Masayuki 高知大学, 教育研究部自然科学系, 講師 (20565741)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 魚病 / ワクチン / 外膜タンパク質 / GAPDH |
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| Research Abstract |
Protective effects of an outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from a bacterium Edwardsiella tarada against other difficult fish diseases, pseudotuberculosis and nocardiosis, was investigated using yellowtail (Seriola quinqueradiata). The fish immunized with GAPDH did not show enough level of protection against both diseases. However, it showed the growth inhibition of infecting Nocardia inside fish body, increased the production of immunoglobulin, and stimulated some immuno-competent genes. Fish pathogenic Mycobacterium sp. was found to be a model bacterium that may show pathogenicity to humans.
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