2013 Fiscal Year Final Research Report
Quantitative analysis of nociceptive and motor reflexes in genetically modified mice
| Project/Area Number |
23380170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Shigeo 北海道大学, (連合)獣医学研究科, 特任教授 (40109509)
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| Co-Investigator(Renkei-kenkyūsha) |
OTSUGURO Ken-ichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 脊髄 / 新生仔マウス / 鎮痛薬 / 反射電位 / キシラジン / α２受容体 / デクスメデトミジン |
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| Research Abstract |
alpha-Adrenoceptor agonists, dexmedetomidine and xylazine inhibited spinal motor and nociceptive reflex potentials. In the alpha2A receptor-functional deficient D79N mice, the inhibitory effect on nociceptive but not motor reflex potentials by these agonists was attenuated. alpha2A-Receptors are suggested to be involved in the alpha2-agonist-evoked analgesia but not the inhibition of motor reflex. Adenosine and hydrogen sulfide (H2S) influence spinal neuronal activity. In the spinal astrocytes, the adenosine metabolic inhibitors released adenosine, while Ca2+-removal released ATP, which was degraded to adenosine. In the neurons, H2S is produced by the synthase CST/MPST.
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Research Products
(17 results)
