A novel physiological function of mast cells on tissue remodeling

2013 Fiscal Year Final Research Report

• Project/Area Number: 23380175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kitasato University
• Principal Investigator: KAWAMINAMI Mitsumori 北里大学, 獣医学部, 教授 (00153007)
• Co-Investigator(Kenkyū-buntansha): YONEZAWA Tomohiro 東京大学, 大学院・農学生命科学研究科, 准教授 (10433715) ; HASHIMOTO Osamu 北里大学, 獣医学部, 講師 (90317058)
• Co-Investigator(Renkei-kenkyūsha): HASEGAWA Yoshihisa 北里大学, 客員教授 (40092001)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: マスト細胞 / 組織リモデリング / 卵巣 / 前立腺 / 乳腺

Research Abstract

Remarkable results are summarized as following. 1) The expressionof GnRH receptor in the mammary gland is augmented after weaning. 2) The number of ovarian mast cells varies during an estrous cycle with two peaks. Those peaks matched with the variation of ovarian expression of GnRH mRNA. 3) As a tissue remodeling model, the changes in histology and mast cell number of prostate were examined after orchidectomy. Mast cell, GnRH and annexin A5 all were increased in the prostate gland after orchidectomy. 4) We found two new signaling agents in the gonadotropes those expression was increased by GnRH. By this research the existence of a novel physiological function at tissue remodeling of mast cell was demonstrated.

Research Products

• [Journal Article] Loss of maternal annexin A5 increases the likelihood of Placental platelet thrombosis and foetal loss (2012)
  • Author(s): Ueki H, Mizushina T, Laharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachyogel B, Poschl E, Kawaminami M
  • Journal Title: Scientific reports Volume: 2 Pages: 827
  • DOI: 10.1038/srep00827
  • Peer Reviewed
• [Presentation] 去勢後のラット前立腺退縮に伴うマスト細胞の浸潤とGnRH-アネキシンA5 系の変化 (2013)
  • Author(s): 空 純子, 米澤智洋, 久留主志朗, 汾陽光盛
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜市(岐阜県)
  • Year and Date: 2013-09-20
• [Presentation] ゴナドトロフにおけるMyxovirus resistance 1(Mx1)のイントロン複合型mRNAの発現 (2013)
  • Author(s): 寺島涼太, 米澤智洋, 久留主志朗, 汾陽光盛
  • Organizer: 第28回日本下垂体研究会
  • Place of Presentation: 花巻市(岩手県)
  • Year and Date: 2013-08-08
• [Presentation] Interferon (IFN) -alpha stimulates the accumulation of Myxovirus (influenza virus) resistance 1 (Mx1) pseudo-gene transcripts including an intron-containing transcript in mouse pituitary gonadotropes (2013)
  • Author(s): Terashima R, Laoharatchatathanin T, Yonezawa T, Kurusu S, Kato, T, Kato Y, Kawaminami M
  • Organizer: possible relation to intra-pituitary action of IFN-alpha
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2013-06-15
• [Presentation] ゴナドトロピン放出ホルモン(GnRH)による抗ウイルス遺伝子myxovirus resistance 1(Mx1)mRNA 発現の変動 (2012)
  • Author(s): 寺島涼太, 米澤智洋, 久留主志朗, 汾陽光盛
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 盛岡市(岩手県)
  • Year and Date: 2012-09-15
• [Presentation] Changes in number of ovarian mast sells during estrous cycle, pseudopregnancy and pregnancy of rats : implications for the expression of gonadotropin releasing hormone (GnRH) in the ovary (2011)
  • Author(s): ラウハラッチャダタニン ティタリー, 寺島涼太, 米澤智洋, 久留主志朗, 汾陽光盛
  • Organizer: 第104回日本繁殖生物学会
  • Place of Presentation: 盛岡市(岩手県)
  • Year and Date: 2011-09-16
• [Remarks]
  • URL: http://www2.vmas.kitasato-u.ac.jp/physiology/Lab_of_Vet_Physiology/Welcome.html
• [Patent(Industrial Property Rights)] 細胞増殖抑制剤 (2012)
  • Inventor(s): 汾陽光盛
  • Industrial Property Rights Holder: 学校法人北里研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許5320719号
  • Acquisition Date: 2012-07-06