Deprotonative Functionalization of Heteroaromatics Using Organocatalytic Systems

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390002
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: KONDO Yoshinori 東北大学, 薬学研究科(研究院), 教授 (90162122)
• Research Collaborator: TANAKA Yoshiyuki ; INAMOTO Kiyofumi ; KUMADA Kanako ; SASAKI Midori
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 有機触媒 / 芳香環 / 脱プロトン化 / 分子変換 / 官能基 / 選択性 / 芳香複素環 / 結合活性化

Outline of Final Research Achievements

Conventionally organometallic chemistry has been used for functionalization of heteroaromatic compounds. From viewpoint of new selectivity and environmental sustainability, I focused my interest on the development of metal-free method for functionalization of heteroaromatic compounds. I successfully developed the catalytic functionalization using onium amide which derived from the combination of onium fluorides and aminosilanes. Another catalytic reaction developed in this project is the direct silylation of heteroaromatic compounds using trifluoromethylsilane and fluoride, which reaction is compatible with various functinal groups including nitro group.

Free Research Field

有機反応化学