Development of Boron Delivery System for Neutron Capture Therapy as a Minimally Invasive Cancer Therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390013
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Tokyo Institute of Technology (2012-2013); Gakushuin University (2011)
• Principal Investigator: NAKAMURA Hiroyuki 東京工業大学, 資源化学研究所, 教授 (30274434)
• Co-Investigator(Kenkyū-buntansha): SATO Shinichi 東京工業大学, 資源化学研究所, 助教 (20633134)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Minoru 京都大学, 原子炉実験所, 教授 (00319724) ; BAN Hyun Seung 学習院大学, 理学部, 助教 (60433710)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 中性子捕捉療法 / リポソーム / ドラッグデリバリーシステム / ホウ素ナノカプセル

Outline of Final Research Achievements

Boron neutron capture therapy (BNCT) is based on the capture reaction of thermal neutrons and nonradioactive 10B, which produces an α-particle and a lithium-7 nuclei ion with approximately 2.4 MeV. We developed the liposomes with high boron contents as efficient boron delivery vehicles for BNCT. We optimized DSBL contents in the liposome preparation and found that 10% DSBL liposome is stable in blood circulation. Furthermore, we succeeded in encapsulation of BSH into the vacant inner of the 10% DSBL liposomes, producing the liposomes with high boron contents. We examined boron biodistribution in the tumor-bearing mice by injection of BSH-encapsulating DSBL liposomes via the tail vein. High boron accumulation was observed in the tumor tissue 36 h after injection of the liposomes. Significant tumor growth suppression was observed in the boron-loaded mice after neutron irradiation.

Free Research Field

有機化学