2013 Fiscal Year Final Research Report
Development of a novel type worm-like DDS penetrable into tumor tissue
| Project/Area Number |
23390014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIY Hiroyuki 前京都薬科大学, 薬学部, 講師 (00403402)
HAMA Susumu 京都薬科大学, 薬学部, 講師 (60438041)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ナノDDS / 癌細胞間隙 / 癌微小環境 |
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| Research Abstract |
In this study, we attempted to develop a novel type worm-like DDS for overcoming drawbacks of conventional nanoDDS for anticancer therapy, such as, antigenicity of PEG, low cell affinity and low permeability into tumor tissue. As the results, we successfully developed charge-invertible liposomes, which can response to tumor microenvironment, and the capabilities of endosomal escape and cellular internalization and tumor accumulation comparable to PEG-liposomes were confirmed. Moreover, the worm-like nanostructures, which can penetrate into narrow space, were developed, and significantly high permeability into spheroids was achieved by improvement of physicochemical property of wick structure, modification with hyaluronidase and functional peptides. Then, integration of those functional liposomes, and evaluation of in vivo functionality was started.
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[Journal Article] Development of a novel nanoparticle by dual modification with the pluripotential cell-penetrating peptide PepFect6 for cellular uptake, endosomal escape, and decondensation of an siRNA core complex2013
Author(s)
Mitsueda A, Shimatani Y, Ito M, Ohgita T, Yamada A, Hama S, Gräslund A, Lindberg S, Langel U, Harashima H, Nakase I, Futaki S, Kogure K
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Journal Title
Biopolymers
Volume: Vol.100
Pages: 698-704
DOI
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