2013 Fiscal Year Final Research Report
Analysis of signaling pathways involved in liver development, regeneration and disease using mice and medaka
| Project/Area Number |
23390018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NISHINA Hiroshi 東京医科歯科大学, 難治疾患研究所, 教授 (60212122)
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| Co-Investigator(Kenkyū-buntansha) |
ASAOKA Yoichi 東京医科歯科大学, 難治疾患研究所, 助教 (10436644)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 肝臓 / シグナル伝達 / モデル生物 / JNK / Hippo / 肝細胞がん / 細胞競合 / 再生 |
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| Research Abstract |
JNK singaling pawatyway is essential for liver development and Hippo signaling pathway regulates liver size. Interestingly, we fond that there is a cross talk between JNK and Hippo signaling pathways. Furthermore, we found that active YAP downstream Hippo signal could form hepatocellular carcinoma and induce cell competition. These results indicate that the Hippo-YAP pathway acts as a stress sensor to eliminate unfit cells in order to safeguard organ size and protect against tumourigenesis.
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[Journal Article] Control of the Hippo pathway by Set7-dependent methylation of Yap2013
Author(s)
Menno J. Oudhoff, Spencer A. Freeman, Amber L. Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H. Min, Jeffrey P. Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Hiroshi Nishina, Michael R. Gold, Fabio M.V. Rossi, Anne-Claude Gingras, and Colby Zaph
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Journal Title
Dev. Cell
Volume: 26
Pages: 188-194
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