2013 Fiscal Year Final Research Report
Proteomic and metabolomic analysis on chemo-sensitivity and resistance of cancer towards personalized medicine
| Project/Area Number |
23390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Koji 慶應義塾大学, 医学部, 特任講師 (00398249)
NISHIMUTA Akito 慶應義塾大学, 医学部, 特任助教 (00424135)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 抗がん剤 / 薬剤反応性 / プロテオーム / メタボローム / オーダーメイド医療 |
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| Research Abstract |
Inter-patient variability in the efficacy of cancer pharmacotherapy is one of the most difficult obstacles to improve cancer therapy. The present research investigated cellular mechanisms of pharmacological action of chemotherapeutic agents and resistant mechanisms of cancer against the drug action. The methods we used were the latest proteomic and metabolomic analyses which measured intracellular expression of abundant proteins and metabolites. Based on comprehensive metabolomic fingerprints and protein expression analysis, we have discovered several new proteins and metabolites that are related to the chemo-sensitivity or drug resistance of cancer. These findings are expected to lead to develop a new personalized cancer pharmacotherapy.
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[Journal Article] Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients2013
Author(s)
Hirasawa A, Zama T, Akahane T, Nomura H, Kataoka F, Saito K, Okubo K, Tominaga E, Makita K, Susumu N, Kosaki K, Tanigawara Y, Aoki D
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Journal Title
J Hum Genet
Volume: 58(12)
Pages: 794-8
DOI
Peer Reviewed
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[Journal Article] A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese2012
Author(s)
Kiyotani K, Mushiroda T, Tsunoda T, Morizono T, Hosono N, Kubo M, Tanigawara Y, Imamura CK, Flockhart DA, Aki F, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H
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Journal Title
Hum Mol Genet
Volume: 21(7)
Pages: 1665-72
DOI
Peer Reviewed
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[Patent(Industrial Property Rights)] 抗がん剤感受性判定マーカー2014
Inventor(s)
谷川原祐介, 渡辺光博, 有田恵理, 西牟田章戸, 山吉康子, 松崎 健, 杉本伸二
Industrial Property Rights Holder
学校法人慶應義塾, 株式会社ヤクルト本社
Industrial Property Rights Type
特許(欧州)
Industrial Property Number
European patent No. 2237042
Acquisition Date
2014-03-12
Overseas
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[Patent(Industrial Property Rights)] 抗がん剤の感受性の判定方法2012
Inventor(s)
谷川原祐介, 西牟田章戸, 鈴木小夜, 鈴木哲也, 生駒祐介, 杉本伸二
Industrial Property Rights Holder
学校法人慶應義塾, 株式会社ヤクルト本社
Industrial Property Rights Type
特許(米国)
Industrial Property Number
US patent 13/504985
Acquisition Date
2012-03-24
Overseas
