Neurobiological mechanisms underlying olfactory bonds

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390050
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kochi University
• Principal Investigator: KABA Hideto 高知大学, 教育研究部医療学系, 教授 (50136371)
• Co-Investigator(Kenkyū-buntansha): OKUTANI Fumino 高知大学, 教育研究部医療学系, 准教授 (10194490) ; TANIGUCHI Mutsuo 高知大学, 教育研究部医療学系, 助教 (10304677) ; MURATA Yoshihiro 高知大学, 教育研究部医療学系, 助教 (40377031)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 匂い / 記憶 / 学習 / 嗅球 / グルタミン酸受容体 / プロテインキナーゼ / タンパク質合成 / ヒストンアセチル化

Research Abstract

In this study we demonstrate that (1) glutamate endogenously released from mitral cells in the accessory olfactory bulb suppresses synaptic transmission from mitral to granule cells by activating mGluR2, a metabotropic glutamate receptor on the pre- and postsynaptic sites, (2) the activation of the protein kinase PKM zeta and new protein synthesis are required for the late phase of long-term potentiation (L-LTP) at the mitral-to-granule cell synapse and (3) epigenetic mechanisms including histone acetylation are critical for aversive olfactory learning and synaptic plasticity at the mitral-to-granule cell synapse of the olfactory bulb in neonatal rats.

Research Products

• [Journal Article] Neurobiology of secure infant attachm ent and attachment despite adversit y : a mouse model (2013)
  • Author(s): Roth TL, Raineki C, Salstein L, Perr y R, Sullivan-Wilson TA, Sloan A, La lji B, Hammock E, Wilson DA, Levitt P, Okutani F, Kaba H, Sullivan RM
  • Journal Title: Genes Brain and Behavior Volume: 12 Pages: 673-680
  • DOI: 10.1111/gbb.12067
  • Peer Reviewed
• [Journal Article] 社会的絆を支える匂いの記憶・学習のメカニズム (2013)
  • Author(s): 椛秀人
  • Journal Title: 分子精神医学 Volume: 13 Pages: 260-266
  • URL: http://www.sentan.com
• [Journal Article] Histone acetylation in the olfactory bulb of young rats facilitates aversive olfactory learning and synaptic p lasticity (2013)
  • Author(s): Wang YJ, Okutani F, Murata Y, Tani guchi M, Namba T, Kaba H
  • Journal Title: Neuroscience Volume: 232 Pages: 21-31
  • DOI: 10.1016/j.neuroscience.2012.12.015
  • Peer Reviewed
• [Journal Article] Regulation of synaptic cur rents by mGluR2 at reciprocal syna pses in the mouse accessory olfact ory bulb (2013)
  • Author(s): Taniguchi M, Yokoi M, Shinohara Y, Okutani F, Murata Y, Nakanishi S, Kaba H
  • Journal Title: European Journal of Neur oscience Volume: 37 Pages: 351-358
  • DOI: 10.1111/ejn.12059
  • Peer Reviewed
• [Journal Article] Evaluation of "Open Essence" odor-identification test card by application to healthy volunteers (2013)
  • Author(s): Okutani F, Hirose K, Kobayashi T, Ka ba H, Hyodo M
  • Journal Title: Auris Nasus Larynx Volume: 40 Pages: 76-80
  • DOI: 10.1016/j.anl.2012.02.007
  • Peer Reviewed
• [Journal Article] 嗅覚 (2013)
  • Author(s): 椛秀人
  • Journal Title: Clinical Neuroscience Volume: 31 Pages: 70-72
  • URL: http://chugaiigaku.jp/
• [Journal Article] Accessory olfactory bulb neurons are required for maintenance but not induction of V2R vomeronasal receptor gene expression in vitro (2011)
  • Author(s): Muramoto K, Hagino-Yamagishi K, Tonosaki K and Kaba H
  • Journal Title: Neuroscience Letters Volume: 500 Pages: 6-9
  • DOI: 10.1016/j.neulet.2011.05.232
  • Peer Reviewed
• [Journal Article] Ameliorative eff ects of Eriobotrya japonica seed ext ract on cellular aging in cultured r at fibroblasts (2011)
  • Author(s): Muramoto K, Quan R-D, Namba T, Kyotani S, Miyamura M, Nishioka Y, Tonosaki K, Doi YL, Kaba H
  • Journal Title: Journal of Natural Medicines Volume: 65 Pages: 254-261
  • DOI: 10.1007/s11418-010-0481-y
  • Peer Reviewed
• [Presentation] マウス副嗅球僧帽細胞-顆粒細胞間相反性シナプス伝達に対するバゾプレッシンの効果 (2014)
  • Author(s): 谷口睦男, 難波利治, 椛秀人
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス, 鹿児島
  • Year and Date: 20140316-18
• [Presentation] オスマウス副嗅球におけるシナプス可塑性に対するバゾプレッシンの役割 (2014)
  • Author(s): 難波利治, 谷口睦男, 村田芳博, 奥谷文乃, 椛秀人
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス, 鹿児島
  • Year and Date: 20140316-18
• [Presentation] マウス副嗅球シナプスの長期増強におけるアクチン重合化の関与 (2014)
  • Author(s): 村田芳博, 椛秀人
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス, 鹿児島
  • Year and Date: 20140316-18
• [Presentation] 嗅覚嫌悪学習はツニカマイシンの嗅球内注入によって阻害される (2014)
  • Author(s): 仝加, 奥谷文乃, 椛秀人
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス, 鹿児島
  • Year and Date: 20140316-18
• [Presentation] フェロモン記憶と個体認知 (2013)
  • Author(s): 椛秀人, 藤田博子, 吾妻 健, 奥谷文乃, 松波宏明
  • Organizer: 日本味と匂学会第47回大会嗅覚シンポジウム「化学シグナルと嗅覚行動および脳機能」
  • Place of Presentation: 仙台市民会館, 仙台
  • Year and Date: 20130905-07
• [Presentation] 感受性期に成立する匂い学習の神経生物学 (2013)
  • Author(s): 椛秀人
  • Organizer: 日本味と匂学会第47回大会日本味と匂学会賞受賞講演
  • Place of Presentation: 仙台市民会館, 仙台
  • Year and Date: 20130905-07
• [Presentation] A suppressing me chanism of the recurrent inhibition by group II metabotropic glutamate receptors activated by endogenous glutamate release from mitral cells in the mouse accessory olfactory bulb (2012)
  • Author(s): Taniguchi M, Kaba H
  • Organizer: XVI International Symposium on Olfaction and Taste
  • Place of Presentation: Stockholm Waterfront, Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] Mate rnally inherited peptides function as strain identity chemosignals in mice (2012)
  • Author(s): Kaba H, Fujita H, Matsunami H
  • Organizer: XVI International Symposium on Olfaction and Taste
  • Place of Presentation: Stockholm Waterfront, Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] A functional role for protein synthesis in long-term potentiation at synapses in the mouse accessory olfactory bulb (2012)
  • Author(s): Murata Y, Kaba H
  • Organizer: XVI In ternational Symposium on Olfaction and Taste
  • Place of Presentation: Stockholm Waterfront, Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] Vasopressin serves to promote the induction of synaptic plasticity in the mouse accessory olfactory bulb (2012)
  • Author(s): Namba T, Taniguchi M, Murata Y, Okutani F, Kaba H
  • Organizer: XVI International Symposium on Olfaction and Taste
  • Place of Presentation: Stockholm Waterfront, Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] Acetylation of histone is involved in the mechanism underlying olfactory learning in young rats (2012)
  • Author(s): Okutani F, Wang Y-J, Kaba H
  • Organizer: XVI Internatio nal Symposium on Olfaction and Taste
  • Place of Presentation: Stockholm Waterfront, Stockholm, Sweden
  • Year and Date: 20120623-27
• [Presentation] バゾプレッシンは副嗅球におけるシナプス可塑性の誘導を促進する (2012)
  • Author(s): 難波利治, 谷口睦男, 村田芳博, 奥谷文乃, 椛秀人
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館, 松本
  • Year and Date: 20120329-31
• [Presentation] 嗅球内シナプス可塑性成立のエピジェネティックメカニズム (2012)
  • Author(s): 奥谷文乃, 王宇杰, 椛秀人
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館, 松本
  • Year and Date: 20120329-31
• [Presentation] 副嗅球シナプスの長期増強における遅延相の新規蛋白合成依存 (2012)
  • Author(s): 村田芳博, 椛秀人
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館, 松本
  • Year and Date: 20120329-31
• [Presentation] 内因性に放出されるグルタミン酸によって活性化される代謝型グルタミン酸受容体mGluR2 を介したマウス副嗅球僧帽細胞-顆粒細胞間相反性シナプス伝達の抑制 (2012)
  • Author(s): 谷口睦男, 椛秀人
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館, 松本
  • Year and Date: 20120329-31
• [Presentation] Long-term potentiation at synapses in the mouse accessory olfactory bulb requires new protein synthesis (2011)
  • Author(s): Murata Y, Kaba H
  • Organizer: The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2011)
  • Place of Presentation: Maidashi campus, Kyushu University, Fukuoka
  • Year and Date: 20111104-06
• [Presentation] A role for epigenetic mechanisms in olfactory learning (2011)
  • Author(s): Wang Y-J, Okutani F, Kaba H
  • Organizer: The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2011)
  • Place of Presentation: Maidashi campus, Kyushu University, Fukuoka
  • Year and Date: 20111104-06
• [Book] 脳神経科学イラストレイテッドー分子・細胞から実験技術まで (2013)
  • Author(s): 椛秀人
  • Total Pages: 229-234
  • Publisher: 羊土社
• [Book] 解剖生理学〔第2版〕 (2012)
  • Author(s): 椛秀人
  • Total Pages: 85-106, 235-242
  • Publisher: 化学同人
• [Book] 調理学 (2011)
  • Author(s): 椛秀人
  • Total Pages: 16-19
  • Publisher: 化学同人
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm