Research on the molecular mechanism of metabolic syndrome and cardiovascular diseases and novel therapeutic strategy for these diseases

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390058
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kumamoto University
• Principal Investigator: MITSUYAMA Shokei (金 勝慶) 熊本大学, 生命科学研究部, 教授 (10195414)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 酸化ストレス / ASK1 / 高血圧 / 動脈硬化 / 認知症 / 脳卒中 / 腎神経 / 高脂肪食

Research Abstract

The role of ASK1 and renal nerve was investigated to examine the molecular mechanism of metabolic syndrome and cerebrovascular and cardiovascular diseases and to develop promising therapeutic strategies for these diseases. ASK1 was involved in cognitive impairment induced by chronic cerebral ischemia or high-fat diet. Renal denervation suppressed the abnormality of blood pressure circadian rhythm and cardiovascular diseases induced by metabolic syndrome and also prevented the onset of cerebrovascular disease, thereby suggesting renal nerve as a promising therapeutic target for cerebrovascular and cardiovascular diseases. Furthermore, ASK2, the ASK1-binding protein, was found to participate in salt-sensitive hypertension and cardiovascular diseases. Thus, ASK1 and renal nerve seem to be a promising therapeutic target for cerebrovascular and cardiovascular diseases.

Research Products

• [Journal Article] Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion (2014)
  • Author(s): Toyama K, Koibuchi N, Uekawa K, Hasegawa Y, Kataoka K, Katayama T, Sueta D, Ma MJ, Nakagawa T, Yasuda O, Tomimoto H, Ichijo H, Ogawa H, Kim-Mitsuyama S
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 34 Pages: 616-25
  • DOI: 10.1161/ATVBAHA.113.302440
  • Peer Reviewed
• [Journal Article] A novel mechanism for disrupted circadian blood pressure rhythm in a rat model of metabolic syndrome - the critical role of angiotensin II (2013)
  • Author(s): Sueta D, Kataoka K, Koibuchi N, Toyama K, Uekawa K, Katayama Ma MingJie, Nakagawa T, Waki H, Maeda M, Yasuda O, Matsui K, Ogawa H, Kim-Mitsuyama S
  • Journal Title: J Am Heart Assoc Volume: 2 Pages: e000035
  • DOI: 10.1161/JAHA.113.000035
  • Peer Reviewed
• [Journal Article] Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome (2013)
  • Author(s): Katayama T, Sueta D, Kataoka K, Hasegawa Y, Koibuchi N, Toyama K, Uekawa K, Mingjie M, Nakagawa T, Maeda M, Ogawa H, Kim-Mitsuyama S
  • Journal Title: J Am Heart Assoc Volume: 2(4) Pages: e000197
  • DOI: 10.1161/JAHA.113.000197
  • Peer Reviewed
• [Journal Article] Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats (2013)
  • Author(s): Nakagawa T, Hasegawa Y, Uekawa K, Ma M, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, Maeda M, Kuratsu J, Kim-Mitsuyama S
  • Journal Title: J Am Heart Assoc Volume: 2(5) Pages: e000375
  • DOI: 10.1161/JAHA.113.000375
  • Peer Reviewed
• [Presentation] RA 系阻害による心血管保護のパラダイムシフト (2013)
  • Author(s): 光山勝慶
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: くまもと県民交流館パレア(熊本)
  • Year and Date: 2013-09-22
• [Presentation] 降圧薬開発の現状と近未来 (2012)
  • Author(s): 光山勝慶
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウエスティンナゴヤキャッスル(名古屋)
  • Year and Date: 2012-09-21
• [Presentation] 高齢化社会を踏まえた高血圧治療戦略-脳卒中, 認知症の治療戦略- (2012)
  • Author(s): 光山勝慶
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウエスティンナゴヤキャッスル(名古屋)
  • Year and Date: 2012-09-21
• [Presentation] 生活習慣病とRAA 系 (2012)
  • Author(s): 光山勝慶
  • Organizer: 第16回日本適応医学会学術集会
  • Place of Presentation: ホテルサンルート有明(東京)
  • Year and Date: 2012-06-09
• [Remarks]
  • URL: http://www.yggcsp.com/Pharmacology/