Molecular mechanisms of genome reprogramming; Somatic cell into pluripotent stem cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: TADA TAKASHI 京都大学, 再生医科学研究所, 准教授 (30188247)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: iPS細胞 / ES細胞 / 多能性幹細胞 / 再プログラム化 / 細胞融合 / エピジェネティクス

Outline of Final Research Achievements

Reprogramming generates conversion of somatic cell into pluripotent stem cell. Molecular mechanisms of somatic reprogramming is explored by iPS cell induction and cell fusion between somatic and ES cells. Here, we demonstrated function of the Sox2, Nanog, Tet1, and Tet2 genes in reprogramming mechanisms, molecular events in X-chromosome reactivation in reprogramming of female somatic cells, applications of the technique of genome editing in iPS cells, differential response between human and mouse iPS cells to culture under the ground state.

Free Research Field

再生医学