2013 Fiscal Year Final Research Report
Investigation of physiological function of linear polyubiquitination using various biological models
| Project/Area Number |
23390070
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 酵素 / タンパク質 / 細胞・ 組織 / 細胞内シグナル伝達 |
|---|
| Research Abstract |
NF-kappaB signaling and interferon production pathway play a pivotal role on biological defense system in various spices. In this study, we identified that SHARPIN is an additional subunit of LUBAC, which produces a novel type of linear polyubiquitin chain and regulates NF-kappaB pathway. Genetic deficiency of SHARPIN causes severe inflammation such as dermatitis in mice. Furthermore, we showed that A20, a deubiquitinatinase, involves evolutionary conserved linear ubiquitin specific binding site at 7th ZF domain. Moreover, we analyzed structure-function study of virus DNA sensor protein, cyclic GMP-AMP synthease (cGAS).
|
Research Products
(34 results)
-
-
[Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin2013
Author(s)
Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Hataguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, and Tamotsu Yoshimori
-
Journal Title
J. Cell Biol
Volume: 203
Pages: 115-128
Peer Reviewed
-
-
-
-
[Journal Article] Non-canonical UBA-UBL interaction mediates formation of linear ubiquitin chain assembly complex2012
Author(s)
Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato
-
Journal Title
EMBO Rep
Volume: 13
Pages: 462-468
Peer Reviewed
-
[Journal Article] Backbone and side chain ^1H, ^<13>C, and ^<15> N assignments of ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex2012
Author(s)
Yoshinori Uekusa, Syunsuke Miura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Oliver, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato
-
Journal Title
Biomol. NMR Assign
Volume: 6
Pages: 177-180
Peer Reviewed
-
-
-
-
-
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis2011
Author(s)
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Benjamin Stieglitz, Caroline Grabbe, Sjoerd van WijK, Mirita Franz-Wachtel, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Boris Macek, Katrin Rittinger, and Ivan Dikic
-
Journal Title
Nature
Volume: 471
Pages: 637-641
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
