Mechanism of atherothrombosis in diabetes mellitus

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390084
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: ASADA Yujiro 宮崎大学, 医学部, 教授 (70202588)
• Co-Investigator(Kenkyū-buntansha): SATO Yuichiro 宮崎大学, 医学部, 准教授 (90347055) ; YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797) ; IMAMURA Takuroh 宮崎大学, 医学部, 准教授 (60203329)
• Co-Investigator(Renkei-kenkyūsha): SHIOMI Masashi 神戸大学, 医学部, 准教授 (50226106)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 病理学 / 糖尿病 / 動脈硬化 / 血栓

Outline of Final Research Achievements

It has been well known that atherosclerosis in diabetic patients is quick in progress, and has a poor prognosis, however, the underlying mechanisms are still unclear. In this study, we examined the mechanism of the development of atherothrombosis in diabetic condition using human atherosclerotic specimens and rabbit atherosclerosis model with or without diabetes mellitus.
The atherosclerotic lesions of rabbit model with diabetes were larger and higher thrombogenic than with non-diabetes, which were similar to those of human lesions. The metabolome analysis identified abount 80 kinds of different metabolites between diabetes and non-diabetes, which were mainly on glucose and amino acid metabolisms. We can expect these metabolites as potential candidates for the new marker of the diabetic atherosclerosis.

Free Research Field

病理学