2013 Fiscal Year Final Research Report
Human natural helper cells and its involvement in diseases
| Project/Area Number |
23390086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Keio University |
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Principal Investigator |
YAMADA TAKETO 慶應義塾大学, 医学部, 准教授 (60230463)
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| Research Collaborator |
HAYASHI Mutsumi 慶應義塾大学, 医学部, 特任助教 (60327575)
NISHIDA Hiroko 慶應義塾大学, 医学部, 特任助教 (80317130)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 病理学 / 免疫学 / メタボリック症候群 / 自然免疫 |
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| Research Abstract |
Pathophysiological examinations of human innate immunology-related natural helper (NH) cells in fat-associated lymphoid cluster (LALC) were done using autopsy cases. FALCs in adipose tissues of total body were analyzed anatomically and histologically, consequently FALC was dominantly located in mesentery and NH cells were most frequent in mesentery as compared to omentum, fat capsule of kidney, genitalia, and retroperitoneum. Hunan NH cells prepared from human mesentery had the same patterns of gene expressions and similar kinds of cytokine production to murine NH cells. Human NH cells labeled with CSFE were transplanted in NOG mice. As a result human NH cells lodged in murine adipose tissues and produced human IL-5 and IL-13 constitutively. The area of FALC and NH cell number was decreased in mesentery of cases with diabetes mellitus and metabolic syndrome as compared to control cases.
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[Journal Article] A homozygous nonsense mutation in the gene for Tmem79, a component for lamellar granule secretory system, produces spontaneous dermatitis in matted mice2013
Author(s)
Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
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Journal Title
J Allergy Clin Immunol
Volume: 132
Pages: 1111-1120
DOI
Peer Reviewed
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[Presentation] A homozygous nonsense mutation of gene for Mattrin , a component of lamellar granule secretory system, produces spontaneous dermatitis in mice2013
Author(s)
Sasaki T, Shiohama A, Kubo A, Kawakami H, Ishida-Yamamoto A, Yamada T, Hachiyama T, Shimizu A, Okano H, Kudoh J, Amagai M
Organizer
International Investigative Dermatology
Place of Presentation
Edinburgh, Scotland
Year and Date
20130508-11
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